217386

Carboxy-PTIO Sodium Salt

≥97% (TLC), Nitric oxide scavenger, solid

• Synonym(s): Carboxy-PTIO, Sodium Salt, 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na
• Empirical Formula (Hill Notation): C₁₄H₁₆N₂O₄ · Na
• Molecular Weight: 299.28
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥97% (TLC)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Properties

• Product Name: Carboxy-PTIO, Sodium Salt, Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2⁻/NO3⁻ with a rate constant of 1 x 10⁴ M⁻¹sec⁻¹.
• Quality Segment: 100
• assay: ≥97% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: dark blue
• solubility: HEPES Buffer: 0.4 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO₂^-/NO₃^- with a rate constant of 1 x 10⁴ M^-1sec^-1. Prevents SIN-1 induced endothelial cell death. Reported to have potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.

Biochem/physiol Actions

Reversible: no

Cell permeable: no

Primary Target
Nitric oxide scavenging action

Product does not compete with ATP.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.

Other Notes

Ishii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
Amano, F., and Nova, J. 1995. FEBS Lett.368, 425.
Hogg, N., et al. 1995. Free Radical Res.22, 47.
Az-ma, T., et al. 1994. Life Sci.54, 185.
Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun.202, 923.
Akaike, T., et al. 1993. Biochemistry32, 827.
Yoshida, K., et al. 1993. Infect. Immun.61, 3552.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable