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T-072

Supelco

Tadalafil solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C22H19N3O4
CAS Number:
Molecular Weight:
389.40
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

SMILES string

O=C1N(C)CC(N2[C@H](C3=CC(OCO4)=C4C=C3)C5=C(C(C=CC=C6)=C6N5)C[C@@]21[H])=O

InChI

1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1

InChI key

WOXKDUGGOYFFRN-IIBYNOLFSA-N

Gene Information

human ... PDE5A(8654)

General description

Tadalafil is an erectile-dysfunction drug marketed under the trade name Cialis®. This Certified Spiking Solution® is suitable for use in numerous testing applications such as clinical toxicology, forensic analysis, urine drug testing, or calibrator preparation.

Application


  • Universal Quantitation of PDE5 Inhibitors: A study highlights the use of high-performance liquid chromatography with charged aerosol detection to universally quantitate undeclared phosphodiesterase-5 inhibitors, including tadalafil, in herbal dietary supplements. This method ensures the integrity of dietary supplements and protects consumers from potential health risks (Poplawska et al., 2013).

  • Drug Screening with 3D-Printed Electrochemical Cells: Research developed a multi-sensor compatible 3D-printed electrochemical cell for voltammetric drug screening, applicable to tadalafil and other drugs. This innovative approach enhances drug analysis efficiency and accuracy, facilitating rapid screening in pharmaceutical research (Ferreira et al., 2021).

  • Solid Dispersions for Enhanced Solubility: A study on the physical stability of solid dispersions of tadalafil in PVP-VA investigates the thermodynamic solubility of the drug, critical for improving bioavailability in pharmaceutical formulations. This research contributes to the development of more effective and reliable drug delivery systems (Wlodarski et al., 2015).


Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Cialis is a registered trademark of Eli Lilly and Co.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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