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N-903

Supelco

Nordiazepam-d5 solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C15D5H6ClN2O
CAS Number:
Molecular Weight:
275.74
EC Number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

[2H]c1c([2H])c([2H])c(c([2H])c1[2H])C2=NCC(=O)Nc3ccc(Cl)cc23

InChI

1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)/i1D,2D,3D,4D,5D

InChI key

AKPLHCDWDRPJGD-RALIUCGRSA-N

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General description

Nordiazepam is a benzodiazepine prescribed for treatment of anxiety and panic attacks. This stable-labeled internal standard is suited for quantitation of nordiazepam levels in urine, serum, or plasma by LC/MS or GC/MS for urine drug testing, clinical toxicology, forensic analysis or isotope dilution methods. Nordiazepam is also a primary urinary metabolite of benzodiazepines diazepam and chlrodiazepoxide.

Application

  • Validation in psychoactive drug detection: A study developed a rapid UPLC-MS/MS method to detect multiple psychoactive substances, including Nordiazepam-d5, in post-mortem whole blood samples, highlighting its utility in forensic toxicology and drug monitoring (Barone et al., 2023).
  • Application in neonatal drug exposure studies: Research employed liquid chromatography-high-resolution mass spectrometry, utilizing Nordiazepam-d5 as a reference, to determine venlafaxine exposure during gestation through neonatal hair analysis, illustrating its value in pediatric forensic investigations (Favretto et al., 2010).
  • Detection in hair samples: The use of Nordiazepam-d5 was explored in a French study for the identification of benzodiazepine consumption in hair samples from drug addicts, demonstrating its effectiveness as a stable isotope-labeled standard for chronic exposure analysis (Vayssette et al., 1996).
  • GC/MS analysis for benzodiazepine metabolites: A method was developed to analyze common benzodiazepine metabolites, including Nordiazepam, in urine, showcasing the application of Nordiazepam-d5 in creating more reliable and reproducible results in toxicological testing (West and Ritz, 1993).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Description
Pricing

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup


Certificates of Analysis (COA)

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