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791334

Sigma-Aldrich

Silica, nanoparticle dispersion in water

<30 nm (DLS), triethoxylpropylaminosilane functionalized

Synonym(s):

NH2 functionalized NPs

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About This Item

UNSPSC Code:
12352302
NACRES:
NA.23

form

dispersion
nanoparticles

shelf life

1 yr

concentration

in water (Dispersion)

particle size

<30 nm (DLS)

density

1.158 g/mL at 25 °C

functional group

amine

storage temp.

20-25°C

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Application

Silica nanoparticles play a crucial role in biotechnology including bone engineering and drug delivery. The amino functionality present on the surface of these materials provides a synthetic handle for further modification and conjugation to target moieties. Amino functionalized silica particles can be used for applicaitons including in vivo gene delivery; nanocomposite formation, and formation of biofilms.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H314,H317

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

8B - Non-combustible corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dhruba J Bharali et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(32), 11539-11544 (2005-07-30)
This article reports on the application of organically modified silica (ORMOSIL) nanoparticles as a nonviral vector for efficient in vivo gene delivery. Highly monodispersed, stable aqueous suspension of nanoparticles, surface-functionalized with amino groups for binding of DNA, were prepared and
Indrajit Roy et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(2), 279-284 (2005-01-05)
This article reports a multidisciplinary approach to produce fluorescently labeled organically modified silica nanoparticles as a nonviral vector for gene delivery and biophotonics methods to optically monitor intracellular trafficking and gene transfection. Highly monodispersed, stable aqueous suspensions of organically modified
Kazuki Murai et al.
Physical chemistry chemical physics : PCCP, 15(27), 11454-11460 (2013-06-12)
We investigated the drug releasing behavior of a novel nanocarrier system, utilizing a peptide to act as a nanogate to the mesopore, on a mesoporous silica nanoparticle. The surface peptide on mesoporous silica displayed pH-dependant mesopore cap-uncap switching behavior, enabled
K C Kavya et al.
Journal of biomedical nanotechnology, 8(1), 149-160 (2012-04-21)
Chitosan, a natural polymer, is a biomaterial which is known to be osteoconductive but lacking in mechanical strength. In this work, to further enhance the mechanical property and biocompatibility of chitosan, we combined it with both chondroitin sulfate, a natural
Preparation and characterization of epoxy composites filled with functionalized nanosilica particles obtained via sol-gel process
Kang, S..;
Polymer, 42(3), 879-887 (2000)
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