- Synthesis of deuterium labeled ketamine metabolite dehydronorketamine-d₄.
Synthesis of deuterium labeled ketamine metabolite dehydronorketamine-d₄.
Bioorganic & medicinal chemistry letters (2011-08-26)
Rohidas S Sulake, Chinpiao Chen, Huei-Ru Lin, Ahai-Chang Lua
PMID21865041
RESUMEN
A convenient synthesis of ketamine metabolite dehydronorketamine-d(4), starting from commercially available deuterium labeled bromochlorobenzene, was achieved. Key steps include Grignard reaction, regioselective hydroxybromination, Staudinger reduction, and dehydrohalogenation.
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