Glycosylation reaction via a mild and efficient one-pot reaction using doped natural phosphate with iodine as catalyst.

Glycosylation reaction via a mild and efficient one-pot reaction using doped natural phosphate with iodine as catalyst.

Nucleosides, nucleotides & nucleic acids (2007-12-07)

H B Lazrek, D Ouzebla, L Baddi, J J Vasseur

RESUMEN

Several alpha/beta-D-ribonucleosides were synthesized in good yields under mild conditions by N-glycosylations of acetyl 2,3,5-tri-O-benzoyl-beta-D-ribofuranose with silylated nucleobases in acetonitrile using NP doped with iodine as catalyst.

MATERIALES

Referencia del producto

Marca

Descripción del producto

225770

Sigma-Aldrich

Litio bis(trimetilsilil)amida solution, 1.0 M in THF

440191

Sigma-Aldrich

Hexamethyldisilazane, reagent grade, ≥99%

245585

Sigma-Aldrich

Sodium bis(trimethylsilyl)amide solution, 1.0 M in THF

702722

Sigma-Aldrich

Potassium bis(trimethylsilyl)amide solution, 1 M in THF

379212

Sigma-Aldrich

Hexamethyldisilazane, ReagentPlus^®, 99.9%

324671

Sigma-Aldrich

Potassium bis(trimethylsilyl)amide, 95%

235083

Sigma-Aldrich

Sodium bis(trimethylsilyl)amide, 95%

277304

Sigma-Aldrich

Potassium bis(trimethylsilyl)amide solution, 0.5 M in toluene

80631

Sigma-Aldrich

Sodium bis(trimethylsilyl)amide solution, 40% in THF

52619

Supelco

Hexamethyldisilazane, for GC derivatization, LiChropur^™, ≥99.0% (GC)

775061

Sigma-Aldrich

Potassium bis(trimethylsilyl)amide solution, 1.0 M in 2-methyltetrahydrofuran

368059

Sigma-Aldrich

Sodium bis(trimethylsilyl)amide solution, 0.6 M in toluene

86944

Sigma-Aldrich

Hexamethyldisilazane, produced by Wacker Chemie AG, Burghausen, Germany, ≥97.0% (GC)

775053

Sigma-Aldrich

Litio bis(trimetilsilil)amida solution, 0.5 M in 2-methyltetrahydrofuran