Lactone-free ginkgolides via regioselective DIBAL-H reduction.

Lactone-free ginkgolides via regioselective DIBAL-H reduction.

Organic & biomolecular chemistry (2005-09-21)

Hideki Ishii, Sergei V Dzyuba, Koji Nakanishi

RESUMEN

The lactone rings of ginkgolide A are converted into corresponding tetrahydrofuran moieties via DIBAL-H reduction followed by deoxygenation of the formed lactols with Et3SiH-BF3.Et2O to produce a series of lactone-free ginkgolides.

MATERIALES

Referencia del producto

Marca

Descripción del producto

215007

Sigma-Aldrich

Hidruro de diisobutilaluminio solution, 1.0 M in toluene

214981

Sigma-Aldrich

Hidruro de diisobutilaluminio solution, 1.0 M in THF

214949

Sigma-Aldrich

Hidruro de diisobutilaluminio solution, 1.0 M in cyclohexane