Solubility Enhancement: Improving Bioavailability of Solid Formulations
Solubility enhancement approaches are of increasing relevance in pharmaceutical product development as a growing number of active pharmaceutical ingredients (APIs) in the pipeline shows low aqueous solubility. As there is no one-size-fits-all solution available, an appropriate fine-tuned approach must be chosen depending on the properties of the API, the desired final dosage form and the required formulation performance. We offer a range of innovative excipients that can boost the efficacy of your final drug product by enhancing API solubility through formulation approaches, as well as through API processing in early development stages.
Our solutions include:
- Specialized excipients for hot melt extrusion, spray drying, dissolution rate enhancement in tableting and a silica drug carrier with a unique surface structure
- API processing chemicals for salt and cocrystal formation
All supported by the Emprove® Program with comprehensive documentation to speed up your way to the market. Whenever applicable, our products are compliant with the major pharmacopeias.
Excellent Solubility Enhancement and Stabilization
Our Parteck® MXP range of polyvinyl alcohol polymers is specifically designed and optimized for hot melt extrusion to increase solubility for a broad range of APIs:
Hydrophilic Lubricant for a Reliable Performance
Our dissolution rate enhancing excipient that also acts as a robust water-soluble, hydrophilic lubricant – designed with the needs of modern solid manufacturing in mind.
Multi-functional for Solubility Enhancement and Particle Engineering
Our innovative Parteck® SLC mesoporous silica is used as a solubility enhancing excipient, stabilizing the more soluble, amorphous form of a compound within nanosized pores.
Meglumine Two Grades, Many Applications
The organic base meglumine can be used as a counterion to form a salt with the API or as a functional excipient to enhance API solubility, improve API stability, and adjust pH value. Select your grade:
Related Product Resources
- Download: Formulation Handbook
In this formulation handbook, we have compiled information and formulation examples that can help you when developing your formulation.
- Article: API Solubility and Dissolution Enhancement Via Formulation
Our overview of API solubility and dissolution enhancement methods can help you decide between the many options to take during formulation.
- Article: Improving API Solubility
This article describes the solubility challenge presented by many small molecule APIs and strategies to overcome these issues during the formulation process.
- White Paper: The Developability Classification System (DCS): Enabling an Optimized Approach for Formulation of Poorly Soluble Molecules
This white paper explores the DCS, a recent advancement based on the BCS system.
- Parteck® MXP White Paper: Enhancing the Solubility of Active Pharmaceutical Ingredients Using Hot Melt Extrusion and Polyvinyl Alcohol
This white paper describes how hot melt extrusion, and a specially engineered grade of polyvinyl alcohol can be used to increase the solubility of DCS IIb molecules.
- Parteck® MXP Brochure: Two Polymers, Unparalleled Value
With two specifically engineered grades of polyvinyl alcohol, our Parteck® MXP polymers are optimal for generating high performing, solubility enhanced formulations via hot melt extrusion.
- Parteck® MXP White Paper: Improving the Bioavailability of Challenging APIs Using Hot Melt Extrusion with Polyvinyl Alcohol
This white paper focuses on using hot melt extrusion (HME) to modify the physical state of APIs with the aim of enhancing solubility by converting the poorly soluble drug from its crystalline form into a stabilized amorphous form.
- Parteck® PLX 188 White Paper: Poloxamer: A Simple and Powerful Solution for Accelerating Dissolution
This white paper introduces the concept of dissolution and discuss how poloxamers are a simple yet powerful formulation approach that can enhance dissolution rate, while minimizing resource requirements.
- Parteck® PLX 188 Brochure: Accelerate Dissolution
Enhance dissolution rate and lubrication with a single high-performance excipient.
- Parteck® SLC Brochure: Adsorb, Stabilize, and Enhance
Unlock amorphous solubility enhancement for even the most challenging compounds.
- Meglumine Brochure: Double Your Benefit with Meglumine
Applicable either as an advanced API intermediate or as a functional excipient.
- Sweeteners Brochure: Two Ways to Ace the Taste Test
Achieve stable formulations and clean, sugar-like taste with our high-intensity sweeteners.
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