PHL89159

Apigenin

phyproof^® Reference Substance

• Sinónimos: 4′,5,7-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
• Fórmula empírica (notación de Hill): C₁₅H₁₀O₅
• Número de CAS: 520-36-5
• Peso molecular: 270.24
• Beilstein: 262620
• Número MDL: MFCD00006831
• Código UNSPSC: 41116107
• NACRES: NA.24

Propiedades

• grado: primary reference standard
• Línea del producto: phyproof^® Reference Substance
• Ensayo: ≥95.0% (HPLC)
• Formulario: powder
• fabricante / nombre comercial: PhytoLab
• mp: >300 °C (lit.)
• cadena SMILES: Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
• Clave InChI: KZNIFHPLKGYRTM-UHFFFAOYSA-N

Descripción

Descripción general

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Acciones bioquímicas o fisiológicas

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G₂/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G₂/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibitory effects on tumor promotion may also be due to inhibition of kinase activity and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I catalyzed DNA religation and enhance gap junctional intercellular communication.

Otras notas

This compound is commonly found in plants of the genus: achillea mentha pimpinella primula salvia silybum thymus

Información legal

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Información de seguridad

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3