Z704474

Lentiviral Vectors

• ISBN-10: 3-54042190-4
• ISBN-13: 978-3-54042190-0
• UNSPSC Code: 55101509

Propiedades

• publication info: D. Trono, Springer, 2002, 258 pp., hard cover

Descripción

General description

The editor provides a compilation of chapters that depict the biological bases underlying the development of lentiviral vectors, describe in detail the various versions of this new gene delivery system, explain the techniques involved in its manufacture, address the all important question of biosafety, discuss thoroughly what currently appear as its most promising applications. Written by the very individual who pioneered the study of HIV-mediated gene transfer and the development of lentiviral vectors, this volume is an essential reading for researchers at all levels of training and interest in the basic applications of gene transfer methods as well as in the medical field of gene therapy.

Table of Contents

Molecular Biology of Lentivirus-Mediated Gene Transfer
HIV-1 Derived Lentiviral Vectors
Lentiviral Vectors Derived from Simian Immunodifficiency Virus
Nonprimate Lentiviral Vectors
Production of Lentiviral Vectors
Biosafety Issues in Lentiviral Production
Lentiviral Vector Targeting
Integration Site Selection by Lentiviruses: Biology and Possible Control
Improving the Post-Transcriptional Aspects of Lentiviral Vectors
Lentiviruses as Vectors for CNS Diseases
Lentiviral Vectors for the Gene Therapy of Lympho-Hematological Disorders
Lentiviral Vectors for Gene Therapy of HIV-Induced Disease
Opportunities for the Use of Lentiviral Vectors in Human Gene Therapy