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Merck

Z3003

Zardaverine

powder, ≥98% (HPLC)

Sinónimos:

6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone

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5 MG

US$ 243,00

US$ 243,00

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Fórmula empírica (notación de Hill):
C12H10F2N2O3
Número CAS:
101975-10-4
Peso molecular:
268.22
UNSPSC Code:
12352202
PubChem Substance ID:
24278784
NACRES:
NA.77
MDL number:
MFCD00867059

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Nombre del producto

Zardaverine,

Quality Level

200

SMILES string

COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2

InChI

1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)

InChI key

HJMQDJPMQIHLPB-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)

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Este artículo
C7971ABS181
Zardaverine

Sigma-Aldrich

Z3003

Zardaverine

Cilostamide phosphodiesterase inhibitor

Sigma-Aldrich

C7971

Cilostamide

Anti-PDE4B2 Antibody from rabbit, purified by affinity chromatography

Sigma-Aldrich

ABS181

Anti-PDE4B2 Antibody

Gene Information

human ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)

Gene Information

human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)

Gene Information

human ... PDE4B(5142)

Quality Level

200

Quality Level

100

Quality Level

100

Application

Zardaverine has been used as a phosphodiesterase inhibitor:
  • to study its effects on human colonic epithelial cells[1]
  • to study its effects on junctional proteins in Sertoli cells[2]
  • to study its effects on phosphodiesterase 3 A (PDE3A) expression in various tumor cells[3]

Biochem/physiol Actions

Zardaverine is a derivative of pyridazinone. It shows anti-tumor and anti-proliferative activity in varied cell lines. Zardaverine possesses broncho-dilatory activity and exhibits therapeutic effects against asthma.[3]
Selective inhibitor of phosphodiesterase III/IV (PDE3/4).

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
SLCR4833
SLCD6156
SLCC9883
SLCC0064
SLBZ8251

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W Fischer et al.
Biochemical pharmacology, 45(12), 2399-2404 (1993-06-22)
Phosphodiesterase inhibitors were used as a tool to manipulate cellular nucleotide levels in vitro and in vivo. The lipopolysaccharide (LPS)-induced release of tumor necrosis factor alpha (TNF-alpha) from mouse peritoneal macrophages was inhibited by prostaglandin E2 with an IC50 of
D T Schmidt et al.
British journal of pharmacology, 131(8), 1607-1618 (2001-01-05)
Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE) block allergen-induced contraction of passively sensitized human airways in vitro by a dual mechanism involving a direct relaxant effect on smooth muscle and inhibition of histamine and cysteinyl leukotriene (LT) release from airways.
A Hatzelmann et al.
British journal of pharmacology, 114(4), 821-831 (1995-02-01)
1. The effect of non-selective (3-isobutyl-1-methylxanthine, IBMX; theophylline) and type IV- or type III/IV-selective (rolipram, RP 73401; zardaverine, tolafentrine) phosphodiesterase (PDE) inhibitors on human eosinophil functions was investigated. 2. For this purpose human eosinophils were purified from blood of healthy
K F Rabe et al.
The American journal of physiology, 266(5 Pt 1), L536-L543 (1994-05-01)
The effects of the nonselective phosphodiesterase (PDE) inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the selective PDE inhibitors motapizone (type III), rolipram (type IV), zardaverine (type III/IV), and zaprinast (type V and I) on prostaglandin F2 alpha (PFG2 alpha)-induced tone in human pulmonary
K F Rabe et al.
The American journal of physiology, 264(5 Pt 1), L458-L464 (1993-05-01)
The effects of the nonselective phosphodiesterase (PDE)-inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the selective PDE inhibitors SKF 94120 (type III), rolipram (type IV), zardaverine (type III/IV), and zaprinast (type V) on inherent tone in human airways were investigated. Substantial relaxation was achieved
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Número de artículo de comercio global

SKUGTIN
Z3003-5MG04061832950099

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