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Merck

V5764

Sigma-Aldrich

Anti-Vesicular GABA Transporter antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-VGAT

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

potency

2-4 mg per mL effective concentration (determined by immunoblotting, using mouse brain and rat brain extracts)

mol wt

antigen ~55 kDa

species reactivity

rat, mouse

packaging

pkg of 200 μL

storage condition

avoid repeated freeze/thaw cycles (Storage in "frost-free" freezers is not recommended)

concentration

~1.0 mg/mL

technique(s)

microarray: suitable
western blot: 2-4 μg/mL using mouse brain and rat brain extracts (S1 fraction)

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

General description

Vesicular GABA transporter (VGAT), also known as solute carrier family 32 member 1 (SLC32A1) or vesicular inhibitory amino acid transporter (VIAAT), is encoded by the gene localized on human chromosome 20q11.23. The encoded protein is highly expressed in both γ-aminobutyric acid -ergic (GABAergic) and glycinergic nerve endings.

Immunogen

synthetic peptide corresponding to amino acids 1-20 located at the N-terminus of mouse VGAT. This sequence is identical in rat VGAT and highly conserved (single a.a. substitution) in human VGAT.

Application

Anti-Vesicular GABA Transporter antibody produced in rabbit has been used in:
  • immunohistochemistry
  • western blot
  • immunocytochemistry

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biochem/physiol Actions

Vesicular GABA transporter (VGAT) plays a vital role in loading of presynaptic vesicles with glycine and γ-aminobutyric acid (GABA). VGAT is precisely involved in packing GABA into synaptic vesicles. In addition, it also has a crucial role in inhibitory synaptic transmission. Genetic variations in the gene leads to hyperekplexia.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Distribution and Posttranslational Modification of Synaptic ERα in the Adult Female Rat Hippocampus
Tabatadze N
Endocrinology, 154, 2013-2013 (2013)
Dopaminergic neurons inhibit striatal output via non-canonical release of GABA
Tritsch NX
Nature, 490, 262-266 (2012)
Forebrain Ischemia Triggers GABAergic System Degeneration in Substantia Nigra at Chronic Stages in Rats
Lin B
Cardiovascular Psychiatry and Neurology (2010)
Cyclin-Dependent Kinase 5 Is Involved in the Phosphorylation of Gephyrin and Clustering of GABAA Receptors at Inhibitory Synapses of Hippocampal Neurons
Kalbouneh H
PLoS ONE, 9 (2014)
Céline Dinocourt et al.
Epilepsia, 52(9), 1656-1665 (2011-06-04)
Epilepsy is a significant long-term consequence of traumatic brain injury (TBI) and is likely to result from multiple mechanisms. One feature that is common to many forms of TBI is denervation. We asked whether chronic partial denervation in vivo would

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