T9514
Tetrahydropapaverine hydrochloride
≥90%, powder
Sinónimos:
6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
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About This Item
Fórmula empírica (notación de Hill):
C20H25NO4 · HCl
Número de CAS:
Peso molecular:
379.88
Número CE:
Número MDL:
Código UNSPSC:
12352200
Productos recomendados
Ensayo
≥90%
Formulario
powder
color
white
solubilidad
H2O: soluble
temp. de almacenamiento
2-8°C
cadena SMILES
Cl.COc1ccc(CC2NCCc3cc(OC)c(OC)cc23)cc1OC
Acciones bioquímicas o fisiológicas
Phosphodiesterase inhibitor.
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
dust mask type N95 (US), Eyeshields, Gloves
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I Koshimura et al.
Brain research, 773(1-2), 108-116 (1997-12-31)
We report the toxic effects of 3,4-dimethoxyphenylethylamine (DMPEA), and tetrahydropapaverine (THP) on the rat nigrostriatal system; THP is a tetrahydroisoquinoline compound which may be derived from DMPEA by conjugation of DMPEA and its oxidative metabolite, dimethoxyphenylacetaldehyde; both are potent inhibitors
S Hosztafi et al.
Pharmacological research, 32(1-2), 15-20 (1995-07-01)
This review surveys the discovery of endogenous alkaloids in mammals. The formation of morphine in mammalian brain was assumed in 1970. The existence of morphine was demonstrated by radioimmunoassay. Identification of morphine was performed by spectroscopic methods. The isolation of
Eung Il Kim et al.
Life sciences, 75(16), 1949-1957 (2004-08-13)
The inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in serotonin-producing murine mastocytoma P815 cells were investigated. Tetrahydropapaverine at concentration ranges of 5-20 microM decreased serotonin content in a concentration-dependent manner in P815 cells and showed 42.1% inhibition of serotonin content
F S Messiha
Veterinary and human toxicology, 32(2), 126-130 (1990-04-01)
The effects of tetrahydropapaverine (THP) and papaverine (PAP), an O-methylated analogue, on rat liver alcohol dehydrogenase (L-ADH) and aldehyde-dehydrogenase (L-ALDH) were studied in vitro. The action of THP on these enzymes was also evaluated in vivo in conjunction with its
K Suzuki et al.
Neurochemical research, 15(7), 705-710 (1990-07-01)
Since the discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism, it has been postulated that (a) MPTP-like toxin(s) such as 1,2,3,4-tetrahydroisoquinoline (TIQ) may induce Parkinson's disease. As the neuronal degeneration in MPTP-induced parkinsonism is thought to be caused by the inhibition of the
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