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T8325

Sigma-Aldrich

TDZD-8

≥98% (HPLC), needles

Sinónimos:

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

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About This Item

Fórmula empírica (notación de Hill):
C10H10N2O2S
Número de CAS:
327036-89-5
Peso molecular:
222.26
MDL number:
MFCD04973552
UNSPSC Code:
12352200
PubChem Substance ID:
329826879
NACRES:
NA.77

assay

≥98% (HPLC)

form

needles

storage condition

protect from light

color

white

mp

63-64.4 °C

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

CN1SC(=O)N(Cc2ccccc2)C1=O

InChI

1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

InChI key

JDSJDASOXWCHPN-UHFFFAOYSA-N

Application

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

Biochem/physiol Actions

TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.

Features and Benefits

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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