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T7783

Sigma-Aldrich

Thonzonium bromide

Sinónimos:

Hexadecyl(2-[(p-methoxybenzyl)-2-pyrimidinylamino]ethyl)dimethylammonium bromide

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About This Item

Fórmula lineal:
C32H55N4OBr
Número de CAS:
553-08-2
Peso molecular:
591.71
EC Number:
209-032-1
MDL number:
MFCD00133855
UNSPSC Code:
12161900
PubChem Substance ID:
24900475

description

cationic

mol wt

591.71 g/mol

application(s)

sample preparation

SMILES string

Br.CCCCCCCCCCCCCCCC[N](C)(C)CCN(Cc1ccc(OC)cc1)c2ncccn2

InChI

1S/C32H55N4O.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-27-36(2,3)28-26-35(32-33-24-19-25-34-32)29-30-20-22-31(37-4)23-21-30;/h19-25H,5-18,26-29H2,1-4H3;1H

InChI key

PBWQBSCBSFJTLE-UHFFFAOYSA-N

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Application

Thonzonium bromide may be use to inhibit vacuolar ATPases (V-ATPases) to induce and study the effects of cytosolic acidification. Thonzonium bromide is also used to further characterize V-ATPases. Thonzonium bromide is use as a potential pDNA particle condenser.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

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A multifunctional nano device as non-viral vector for gene delivery: in vitro characteristics and transfection.
Gao Y, Gu W, Chen L, Xu Z, Li Y.
J. Controlled Release, 118, 381-388 (2007)
Ryosuke Suzuki et al.
Biological & pharmaceutical bulletin, 31(6), 1237-1243 (2008-06-04)
Non-viral DNA vectors are promising gene delivery systems and a variety of non-viral DNA vectors have been developed to date. Recently, we developed a novel non-viral gene delivery system--multifunctional envelope-type nano device (MEND). The MEND system has high transfection activity
Rebecca M Johnson et al.
Analytical biochemistry, 398(2), 203-211 (2009-12-19)
Fluorescence intensity of the pH-sensitive carboxyfluorescein derivative 2,7-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) was monitored by high-throughput flow cytometry in living yeast cells. We measured fluorescence intensity of BCECF trapped in yeast vacuoles, acidic compartments equivalent to lysosomes where vacuolar proton-translocating ATPases (V-ATPases) are
Chun-Yuan Chan et al.
The Journal of biological chemistry, 287(13), 10236-10250 (2012-01-05)
Vacuolar ATPases (V-ATPases) are important for many cellular processes, as they regulate pH by pumping cytosolic protons into intracellular organelles. The cytoplasm is acidified when V-ATPase is inhibited; thus we conducted a high-throughput screen of a chemical library to search
Cristiana Lalli et al.
PLoS neglected tropical diseases, 9(1), e0003484-e0003484 (2015-01-31)
Schistosomiasis, one of the world's greatest neglected tropical diseases, is responsible for over 280,000 human deaths per annum. Praziquantel, developed in the 1970s, has high efficacy, excellent tolerability, few and transient side effects, simple administration procedures and competitive cost and

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