T5515

Thionicotinamide adenine dinucleotidephosphate sodium salt

≥95%

• Sinónimos: Thionicotinamid-TPN sodium salt, Thionicotinamide-TPN, Triphosphothiopyridine nucleotide sodium salt
• Fórmula lineal: C₂₁H₂₇N₇O₁₆P₃S · Na
• Número de CAS: 19254-05-8
• Peso molecular: 781.45
• MDL number: MFCD00079598
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278061

Propiedades

• assay: ≥95%
• solubility: H₂O: soluble 50 mg/mL, clear, yellow to very deep yellow
• storage temp.: −20°C
• SMILES string: [Na+].NC(=S)c1ccc[n+](c1)[C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)([O-])=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O
• InChI: 1S/C21H28N7O16P3S.Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(43-45(32,33)34)14(30)11(42-21)6-40-47(37,38)44-46(35,36)39-5-10-13(29)15(31)20(41-10)27-3-1-2-9(4-27)18(23)48;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,48);/q;+1/p-1/t10-,11-,13-,14-,15-,16-,20-,21-;/m1./s1
• InChI key: RFGBSJGYGUYCBT-QYZPTAICSA-M

Descripción

Application

Thio-NADP has been identified as a compound unique to the β-arrestin CNR2 screening assay⁴.

Biochem/physiol Actions

Blocks nicotinate adenine dinucleotide phosphate (NAADP)-induced Ca²⁺ release

Studies using sea-urchin egg homogenates have reported that thio-NADP stimulates partial Ca²⁺ release at 50 μm and blocks successive challenge with a saturating concentration of nicotinic acid adenine dinucleotide phosphate (NAADP). Subsequent HPLC purification analysis have reported that Ca²⁺ release function of thio-NADP is because of the presence of NAADP as a contaminant. Hence, this study challenges the NAADP antagonist functions of thio-NADP and indicates that thio-NADP does not function as an NAADP blocker⁵.

Linkage

Analog of NADP

Preparation Note

Thionicotinamide adenine dinucleotidephosphate (thio-NADP) sodium is soluble in water at 50 mg/ml and yields a clear, yellow to dark yellow solution.

Información de seguridad

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)