Saltar al contenido
Merck
Todas las fotos(1)

Documentos

T4057

Sigma-Aldrich

Tyrphostin AG 1296

≥98%

Sinónimos:

6,7-Dimethoxy-2-phenylquinoxaline

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C16H14N2O2
Número de CAS:
146535-11-7
Peso molecular:
266.29
MDL number:
MFCD00270913
UNSPSC Code:
12352200
PubChem Substance ID:
329826783

assay

≥98%

form

powder

solubility

methylene chloride: soluble 10 mg/mL
DMSO: soluble

storage temp.

2-8°C

SMILES string

COc1cc2ncc(nc2cc1OC)-c3ccccc3

InChI

1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3

InChI key

QNOXYUNHIGOWNY-UHFFFAOYSA-N

Biochem/physiol Actions

Studies have reported that phosphorylation of tyrosine 857 in PDGF β-receptor is the most susceptible to inhibition by tyrphostin AG 12962.
Selective inhibitor of platelet-derived growth factor (PDGF) receptor protein.

Preparation Note

Tyrphostin AG 1296 is soluble in methylene chloride at 10 mg/ml and is also soluble in DMSO.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Nathan G Dolloff et al.
Cancer research, 67(2), 555-562 (2007-01-20)
The factors regulating the bone tropism of disseminated prostate cancer cells are still vaguely defined. We report that prostate cancer cells that metastasize to the skeleton respond to human bone marrow with a robust stimulation of the phosphatidylinositol 3-kinase/Akt pathway
Saher Hamed et al.
PloS one, 5(11), e13986-e13986 (2010-11-19)
Autologous transplanted fat has a high resorption rate, providing a clinical challenge for the means to reduce it. Erythropoietin (EPO) has non-hematopoietic targets, and we hypothesized that EPO may improve long-term fat graft survival because it has both pro-angiogenic and
Ruei-Zeng Lin et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(28), 10137-10142 (2014-07-02)
Endothelial colony-forming cells (ECFCs) are endothelial precursors that circulate in peripheral blood. Studies have demonstrated that human ECFCs have robust vasculogenic properties. However, whether ECFCs can exert trophic functions in support of specific stem cells in vivo remains largely unknown.
Susanne Dell et al.
Investigative ophthalmology & visual science, 47(5), 1928-1937 (2006-04-28)
Corneal neovascularization remains an unsolved therapeutic problem. Platelet-derived growth factor (PDGF) is directly linked to vessel formation and stabilization. This study was undertaken to elucidate the mechanisms by which PDGF exerts its effects on corneal angiogenesis. Corneal neovascularization was induced
Kate Chao-Wei Chen et al.
Molecular vision, 13, 374-387 (2007-03-30)
The mitogenic action of PDGF has been shown to associate with reactive oxygen species (ROS) generation, but the mechanism leading to ROS production and subsequent cell proliferation is not clear. We investigated the upstream membrane-bound target proteins involved in PDGF-stimulated
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico