SRP6312

Alpha 1 Antitrypsin from human plasma

HBsAg, HCV, HBc free, ≥95% (SDS-PAGE)

• Sinónimos: AAT, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, PI, Serpin A1
• Código UNSPSC: 12352202
• NACRES: NA.32

Propiedades

• origen biológico: human
• Ensayo: ≥95% (SDS-PAGE)
• Formulario: lyophilized
• potencia: ≥5.0 I.U. per mg
• mol peso: 52 kDa
• envase: pkg of 1 mg
• Nº de acceso UniProt: P01009
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... Serpin A1(5265)

Descripción

Descripción general

Our Alpha 1 Antitrypsin is a human plasma protein.It is shown to be HBsAg, HCV, HBc free and also negative for anti HIV1 and HIV2 according to FDA approved tests.
The gene AAT (α 1 antitrypsin) is mapped to human chromosome 14q32.1.[1] AAT is an acute-phase plasma protein.[2] It is a water soluble glycoprotein. AAT is mainly secreted by hepatocytes, macrophages, and some cancer cells.[3] AAT is also referred to as Serpin A1.

Aplicación

AAT (α 1 antitrypsin) from human plasma has been used as a standard to check the presence of AAT in benign and malignant lymphoreticular cells and tissues.[4]

Acciones bioquímicas o fisiológicas

AAT (α 1 antitrypsin) functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin and plasminogen activator.[3][5] Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis.[3][6] It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives.[7][8] The simultaneous quantitative determination of AAT and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in AAT occurs as an acute phase response to tissue necrosis and inflammation.[9] It might work as a biomarker for cutaneous squamous cell carcinoma, hepatitis B, insulinomas, NSCLC (non-small cell lung cancer), papillary thyroid carcinoma, lung cancer and breast carcinoma.[10]

Forma física

Lyophilized from 30 mM Na Phosphate, pH 6.5 with 300 mM NaCl.

Reconstitución

In water or aqueous buffer

Información de seguridad

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable