SRP6002
Chemerin human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Sinónimos:
HP10433, RARRES2, TIG2
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About This Item
Productos recomendados
origen biológico
human
recombinante
expressed in E. coli
Ensayo
≥98% (HPLC)
≥98% (SDS-PAGE)
Formulario
lyophilized
mol peso
16.0 kDa
envase
pkg of 25 μg
impurezas
Endotoxin, tested
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... RARRES2(5919)
Descripción general
Chemerin, which is also known as retinoic acid receptor responder 2 (RARRES2), is a chemoattractant expressed in white adipose, liver and lung tissues. It is an immunomodulating factor. The protein is a ligand for the G-protein coupled receptor known as ChemR23 (or chemokine-like receptor-1), which is expressed mainly on dendritic cells, macrophages and some adipocytes. The gene encoding it is localized on human chromosome 7q36.1. Recombinant human Chemerin, produced in Escherichia.coli, is a non-glycosylated protein containing 138 amino acids and having a total molecular mass of 16kDa.
Acciones bioquímicas o fisiológicas
Chemerin activates chemerin-like receptor 1 (CMKLR1) and stimulates chemotaxis in macrophages, natural killer cells and immature dendritic cells. It is also involved in the activation of extracellular signal-regulated kinases, stimulation of blood vessel formation, migration and invasion.
Forma física
Lyophilized from 0.2% TFA.
Reconstitución
Centrifuge the vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile H?O to a concentration of 0.1mg/ml, which can be further diluted into other aqueous solutions.
Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Jun-xian Zhou et al.
Acta pharmacologica Sinica, 35(5), 653-663 (2014-03-25)
The chemerin receptor CMKLR1 is one type of G protein-coupled receptors abundant in monocyte-derived dendritic cells and macrophages, which plays a key role in the entry of a subset of immunodeficiency viruses including HIV/SIV into lymphocytes and macrophages. The aim
Urszula Godlewska et al.
Frontiers in microbiology, 11, 1819-1819 (2020-08-28)
Chronic inflammatory skin diseases like psoriasis alter the local skin microbiome and lead to complications such as persistent infection with opportunistic/pathogenic bacteria. Disease-associated changes in microbiota may be due to downregulation of epidermal antimicrobial proteins/peptides, such as antimicrobial protein chemerin.
The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin.
Jeremy Di Domizio et al.
Nature immunology, 21(9), 1034-1045 (2020-07-15)
Skin wounds heal by coordinated induction of inflammation and tissue repair, but the initiating events are poorly defined. Here we uncover a fundamental role of commensal skin microbiota in this process and show that it is mediated by the recruitment
Association of Polymorphisms in STRA6 and RARRES2 Genes with Type 2 Diabetes in Southern Han Chinese.
Huang HW
BioMed Research International, 2016, 6589793-6589793 (2016)
Rui-Li Zhang et al.
Journal of cellular biochemistry, 120(12), 19621-19634 (2019-07-20)
Chemerin, a chemoattractant protein, is involved in endothelial dysfunction and vascular inflammation in pathological conditions. In a recent study, we observed the upregulation of chemerin in endothelial cells following in vitro treatment with Treponema pallidum. Here, we investigated the role
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