SRP5277

LYN A, active, GST tagged human

PRECISIO^®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Sinónimos: FLJ26625, JTK8
• Código UNSPSC: 12352200
• NACRES: NA.32

Propiedades

• recombinante: expressed in baculovirus infected Sf9 cells
• Línea del producto: PRECISIO^®
• Ensayo: ≥70% (SDS-PAGE)
• Formulario: buffered aqueous glycerol solution
• actividad específica: 434-657 nmol/min·mg
• mol peso: ~81 kDa
• Nº de acceso NCBI: NM_002350
• Condiciones de envío: dry ice
• temp. de almacenamiento: −70°C
• Información sobre el gen: human ... LYN(4067)

Descripción

Descripción general

LYN A is a member of the Src-family of protein kinases that participate in signaling pathways of a variety of cell surface receptors and are localized to the cytoplasmic side of the plasma membrane. LYN A is biosynthetically transported to the plasma membrane via the Golgi pool of caveolin along the secretory pathway. The trafficking of LYN A from the Golgi apparatus to the plasma membrane is inhibited by deletion of the kinase domain but not by kinase inactivation. The kinase domain of LYN A plays a role in LYN A trafficking besides catalysis of substrate phosphorylation. cDNA microarray analysis revealed that LYN A may be involved in the changes that are related to tumor pathogenesis.

Forma física

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Nota de preparación

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Información legal

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable