SRP4542

FGF-19 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• Sinónimos: FGF19, FGFJ, fibroblast growth factor 19
• Código UNSPSC: 12352202
• NACRES: NA.32

Propiedades

• origen biológico: human
• recombinante: expressed in E. coli
• Ensayo: ≥95% (SDS-PAGE)
• Formulario: lyophilized
• potencia: 50-200 ng/mL
• mol peso: ~21.8 kDa
• envase: pkg of 25 μg
• condiciones de almacenamiento: avoid repeated freeze/thaw cycles
• impurezas: endotoxin, tested
• Nº de acceso NCBI: NM_005117
• Nº de acceso UniProt: O95750
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... FGF19(9965)

Descripción

Descripción general

Fibroblast growth factor-19 (FGF-19) is an ileum-derived polypeptide hormone and a high affinity heparin-dependent ligand for fibroblast growth factor receptor 4 (FGFR4). It is part of the hormone-like FGF family. The gene encoding FGF-19 is localized on human chromosome 11q13.3.[1][2][3] Recombinant human FGF-19 is a 21.8kDa protein containing 195 amino acid residues.

Acciones bioquímicas o fisiológicas

Fibroblast growth factor-19 (FGF-19) is involved in the gut-liver signaling pathway and modulation of bile acid synthesis. Once secreted, it binds to the hepatic fibroblast growth factor receptor 4 (FGFR4)/Klotho-β cell-surface receptor complex and activates it. FGF-19 promotes glycogen synthesis, protein synthesis and lipid metabolism.[1][2]

Forma física

Lyophilized from 5 mM Tris, pH 7.6 plus 75 mM NaCl. The protein may appear as a haze or film, which you may not see at the bottom of the vial.

Reconstitución

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1 to 1.0 μg/μL. This solution can then be diluted into other aqueous buffers.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable