SML4078

MitoBloCK-10

≥98% (HPLC)

• Sinónimos: 3-​Fluoro-​benzoic acid 2-​[(5-​nitro-​2-​thienyl)​methylene]​hydrazide, 3-Fluoro-N’- [(5-nitro-2-thienyl)methylene]benzohydrazide, MB-10, Mitochondrial import blockers of the Carla Koehler laboratory-10
• Fórmula empírica (notación de Hill): C₁₂H₈FN₃O₃S
• Número de CAS: 394694-98-5
• Peso molecular: 293.27
• MDL number: MFCD00813373
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Fc1cc(ccc1)C(=O)N\N=C\c2[s]c(cc2)[N+](=O)[O-]
• InChI: 1S/C12H8FN3O3S/c13-9-3-1-2-8(6-9)12(17)15-14-7-10-4-5-11(20-10)16(18)19/h1-7H,(H,15,17)/b14-7+
• InChI key: QDYQZMWFIYLMNX-VGOFMYFVSA-N

Descripción

Biochem/physiol Actions

Mitochondrial import blocker of substances requiring inner membrane translocon TIM23.
MitoBloCK-10 (MB-10) is mitochondrial import blocker of substances requiring inner membrane translocon TIM23 (TIM23) in yeast and mammalian mitochondria. It appears that MB-10 targets Tim44 of the PAM complex. MitoBloCK-10 does not alter respiraton. MB-10 inhibits cardiac development and induces apoptosis in Zebrafish embryos. It inhibits bladder cancer cell growth in vitro and in vivo.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable