Saltar al contenido
Merck
Todas las fotos(1)

Documentos

SML0678

Sigma-Aldrich

Pyridostatin trifluoroacetate salt

≥98% (HPLC)

Sinónimos:

4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide trifluoroacetate salt, RR82 trifluoroacetate salt

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C31H32N8O5 · xC2HF3O2
Número de CAS:
1085412-37-8
Peso molecular:
596.64 (free base basis)
MDL number:
MFCD26142941
UNSPSC Code:
12352202
PubChem Substance ID:
329825581
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

H2O: 15 mg/mL, clear

storage temp.

−20°C

SMILES string

OC(C(F)(F)F)=O.O=C(NC1=CC(OCCN)=C(C=CC=C2)C2=N1)C3=CC(OCCN)=CC(C(NC4=NC(C=CC=C5)=C5C(OCCN)=C4)=O)=N3

InChI

1S/C31H32N8O5.C2HF3O2/c32-9-12-42-19-15-24(30(40)38-28-17-26(43-13-10-33)20-5-1-3-7-22(20)36-28)35-25(16-19)31(41)39-29-18-27(44-14-11-34)21-6-2-4-8-23(21)37-29;3-2(4,5)1(6)7/h1-8,15-18H,9-14,32-34H2,(H,36,38,40)(H,37,39,41);(H,6,7)

InChI key

SLFYRKZWSPFGQZ-UHFFFAOYSA-N

Application

Pyridostatin trifluoroacetate salt has been used as a G-quadruplex (G4) stabilizer to study interactions between RNA G4 and ligand molecules.

Biochem/physiol Actions

Pyridostatin is a highly selective G-quadruplex interacting molecule. It retards the growth of human cancer cells by inducing replication/transcription dependent on DNA damage.
Pyridostatin stabilizes G-quadruplexes, targeting the proto-oncogene SRC and telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.

Other Notes

Light sensitive

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Chandran A
Advancing Development of Synthetic Gene Regulators: With the Power of High-Throughput Sequencing in Chemical Biology. (2017)
RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination.
de Almeida C R, et al.
Molecular Cell (2018)
Investigation of higher-order RNA G-quadruplex structures in vitro and in living cells by 19 F NMR spectroscopy.
Bao H L and Yan X
Nature Protocols, 13(4), 652-652 (2018)
Wei Wu et al.
Nature structural & molecular biology, 27(5), 424-437 (2020-05-14)
Oncogene activation during tumorigenesis generates DNA replication stress, a known driver of genome rearrangements. In response to replication stress, certain loci, such as common fragile sites and telomeres, remain under-replicated during interphase and subsequently complete locus duplication in mitosis in
Diana C Odermatt et al.
PLoS genetics, 16(6), e1008740-e1008740 (2020-06-17)
FANCJ/BRIP1 is an iron-sulfur (FeS) cluster-binding DNA helicase involved in DNA inter-strand cross-link (ICL) repair and G-quadruplex (G4) metabolism. Mutations in FANCJ are associated with Fanconi anemia and an increased risk for developing breast and ovarian cancer. Several cancer-associated mutations
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico