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SML0508

Pentostatin

Name: Pentostatin
Brand: SIGMA
Price: 123 USD

≥95% (HPLC), adenosine deaminase inhibitor, powder

Sinónimos:

(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, 2′-dCF, DCF, Deoxycoformycin

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Talla/SKU	Disponibilidad	Precio
5 mg	Comprobar disponibilidad del carrito	US$ 123,00
25 mg	Comprobar disponibilidad del carrito	US$ 521,00

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₁₁H₁₆N₄O₄

Número CAS:

53910-25-1

Peso molecular:

268.27

UNSPSC Code:

12352200

PubChem Substance ID:

329825517

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

powder

Storage condition:

desiccated

US$ 123,00

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Propiedades

Nombre del producto

Pentostatin, ≥95% (HPLC)

Quality Segment

100

assay

≥95% (HPLC)

form

powder

optical activity

[α]/D +70 to +80°, c = 1 in H₂O

storage condition

desiccated

color

white to beige

solubility

H₂O: 10 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3[C@H](O)CN=CNc23

InChI

1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1

InChI key

FPVKHBSQESCIEP-JQCXWYLXSA-N

Gene Information

human ... ADA(100)

Descripción

Application

Pentostatin has been used in in vivo anti-tumor studies. It has also been used along with cyclophosphamide as a selective B-cell immune suppression regimen to explore solid tumor therapy by selectively targeting stromal endothelial cells.

Biochem/physiol Actions

Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD).

Pentostatin is an immunosuppressant; adenosine deaminase inhibitor; ring-expanded nucleoside (REN).

Pentostatin/2′-deoxycoformycin is used to treat patients with Waldenström′s macroglobulinemia.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Air sensitve; hygroscopic.

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Este artículo	116860
Sigma-Aldrich SML0508 Pentostatin	Sigma-Aldrich 116860 Adenosine Deaminase Inhibitor, DCF
description ≥95% (HPLC)	description The Adenosine Deaminase Inhibitor, DCF, also referenced under CAS 53910-25-1, controls the biological activity of Adenosine Deaminase.
form powder	form solid
assay ≥95% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C
storage condition desiccated	storage condition protect from light, OK to freeze
solubility H₂O: 10 mg/mL, clear	solubility DMSO: 10 mg/mL, clear, colorless, water: 50 mg/mL, clear, colorless

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Pictogramas

GHS06

Palabra de advertencia

Danger

Códigos de peligro

H301

Indicaciones de precaución

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

¿Qué está pasando?

WGK 3

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)