SML0445

Clemastine fumarate salt

≥98% (HPLC)

• Sinónimos: (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, Meclastine fumarate salt, Mecloprodine
• Fórmula empírica (notación de Hill): C₂₁H₂₆ClNO · C₄H₄O₄
• Número de CAS: 14976-57-9
• Peso molecular: 459.96
• Número CE: 239-055-2
• Número MDL: MFCD00137486
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329824727
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• actividad óptica: [α]/D +15 to +25°, c = 1 in methanol
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: DMSO: 5 mg/mL (clear solution; warmed)
• temp. de almacenamiento: room temp
• cadena SMILES: OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3
• InChI: 1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1
• Clave InChI: PMGQWSIVQFOFOQ-YKVZVUFRSA-N
• Información sobre el gen: human ... HRH1(3269)

Descripción

Descripción general

Clemastine fumarate is used to treat multiple sclerosis,[1] sneezing and rhinorrhea linked to common cold.[2] It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination.[1]

Aplicación

Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.[3]

Acciones bioquímicas o fisiológicas

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic.

Características y beneficios

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable