SML0147

Drospirenone

≥98% (HPLC)

• Sinónimos: 6β,7β:15β,16β -Dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone, Dihydrospirorenone
• Fórmula empírica (notación de Hill): C₂₄H₃₀O₃
• Número CAS: 67392-87-4
• Peso molecular: 366.49
• NACRES: NA.77
• PubChem Substance ID: 329825195
• UNSPSC Code: 51111800
• EC Number: 266-679-2
• MDL number: MFCD00867350
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -180 to -195°, c = 1 in methanol
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥15
• originator: Bayer
• storage temp.: 2-8°C
• SMILES string: C[C@]12CCC(=O)C=C1[C@@H]3C[C@@H]3[C@@H]4[C@@H]2CC[C@@]5(C)[C@H]4[C@@H]6C[C@@H]6[C@@]57CCC(=O)O7
• InChI: 1S/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1
• InChI key: METQSPRSQINEEU-HXCATZOESA-N
• Gene Information: human ... NR3C2(4306), PGR(5241)

Descripción

Application

Drospirenone was tested for genotoxicity in rat and human hepatocytes.

Drospirenone has been used as a progestogen agent in pond snail and fish.

Biochem/physiol Actions

Drospirenone is a fourth-generation progestin that has antimineralocorticoid, and antiandrogenic activity in addition to potent progestogenic activity. In two recent studies drospirenone appeared to double the risk of venous thromboembolism compared to levonorgestrel, although other studies found little added risk.

Fourth-generation progestin; contraceptive

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS08
• Palabra de advertencia: Danger
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Códigos de peligro: H351,H360FD
• Hazard Classifications: Carc. 2 - Repr. 1A
• Punto de inflamación (°F): No data available
• Punto de inflamación (°C): No data available
• Indicaciones de precaución: P201 - P202 - P280 - P308 + P313 - P405 - P501