SML0059

BLT-1

≥98% (HPLC)

• Sinónimos: 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20, BLT1, Block lipid transport-1, MIT 9952-53
• Fórmula empírica (notación de Hill): C₁₂H₂₃N₃S
• Número de CAS: 321673-30-7
• Peso molecular: 241.40
• Número MDL: MFCD00571007
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 329825125
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to tan
• solubilidad: DMSO: ≥13 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CCCCCCC1CCC\C1=N/NC(N)=S
• InChI: 1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11+
• Clave InChI: OWGUSBISUVLUJF-SDNWHVSQSA-N

Descripción

Aplicación

BLT-1 (Block lipid transport-1) has been used as an inhibitor of the SR-BI (scavenger receptor, class B, type I) mediated lipid transfer to determine if miR-223-3p export from polymorphonuclear neutrophils (PMNs) to high-density lipoproteins (HDLs) is dependent on SR-BI-mediated lipid flux. It has also been used as a SR-BI inhibitor to study the effect of HDL on osteocalcin (OCN) expression in monocyte cell lines through SR-B1.[1]

BLT-1 may be used to study cell signaling pathways that have role in cholesterol influx and efflux.

Acciones bioquímicas o fisiológicas

Block lipid transport-1 (BLT-1) is a specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer. The compound inhibits both cellular selective lipid uptake of HDL cholesteryl ether and efflux of cellular cholesterol to HDL.

Specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable