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SML0006

Sigma-Aldrich

CK-666

≥98% (HPLC), powder, Arp2/3 comple inhibitor

Sinónimos:

2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide, CK 666, CK-0944666

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About This Item

Fórmula empírica (notación de Hill):
C18H17FN2O
Número de CAS:
442633-00-3
Peso molecular:
296.34
MDL number:
MFCD03036271
UNSPSC Code:
12352200
PubChem Substance ID:
329825083
NACRES:
NA.77

product name

CK-666, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥25 mg/mL

storage temp.

2-8°C

SMILES string

Cc1[nH]c2ccccc2c1CCNC(=O)c3ccccc3F

InChI

1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)

InChI key

UXRKUKRXVWJFER-UHFFFAOYSA-N

Application

CK-666 may be used to study Arp2/3-mediated structural changes in cells.

Biochem/physiol Actions

CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex and prevents its movement into active conformation.
CK-666 is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Satoko Sakamoto et al.
PLoS biology, 16(9), e2004874-e2004874 (2018-09-27)
Formin is one of the two major classes of actin binding proteins (ABPs) with nucleation and polymerization activity. However, despite advances in our understanding of its biochemical activity, whether and how formins generate specific architecture of the actin cytoskeleton and
Akriti Prashar et al.
Frontiers in cellular and infection microbiology, 8, 133-133 (2018-05-19)
Legionella pneumophila (Lp) exhibits different morphologies with varying degrees of virulence. Despite their detection in environmental sources of outbreaks and in respiratory tract secretions and lung autopsies from patients, the filamentous morphotype of Lp remains poorly studied. We previously demonstrated
Shao-Chen Sun et al.
PloS one, 6(4), e18392-e18392 (2011-04-16)
Mammalian oocyte meiotic maturation involves oocyte polarization and a unique asymmetric division, but until now, the underlying mechanisms have been poorly understood. Arp2/3 complex has been shown to regulate actin nucleation and is widely involved in a diverse range of
Yuki M Shirai et al.
PloS one, 12(11), e0188778-e0188778 (2017-12-01)
Electron tomography of the plasma membrane (PM) identified several layers of cortical actin meshwork running parallel to the PM cytoplasmic surface throughout the PM. Here, cortical actin structures and dynamics were examined in living cells, using super-resolution microscopy, with (x,y)-
Byron Hetrick et al.
Chemistry & biology, 20(5), 701-712 (2013-04-30)
Actin-related protein 2/3 (Arp2/3) complex is a seven-subunit assembly that nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to Arp2/3 complex and inhibit nucleation, but their modes of action are unknown. Here, we use biochemical and structural
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