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SCP0110
Cathepsin L Inhibitor
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5 MG
US$ 162,00
US$ 162,00
PRECIOS SIN IMPUESTOS NACIONALES
Normalmente se envía en 2 semanas.
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5 MG
US$ 162,00
About This Item
Fórmula empírica (notación de Hill):
C35H59N11O5
Peso molecular:
713.91
Código UNSPSC:
12352200
NACRES:
NA.32
US$ 162,00
PRECIOS SIN IMPUESTOS NACIONALES
Normalmente se envía en 2 semanas.
Productos recomendados
Ensayo
≥95% (HPLC)
Formulario
lyophilized
composición
Peptide Content, ≥55%
condiciones de almacenamiento
protect from light
temp. de almacenamiento
−20°C
Amino Acid Sequence
Arg-Lys-Leu-Leu-Trp-NH2
Descripción general
Cathepsin L Inhibitor is a histone H3-processing enzyme.[1] It is important for maintaining epidermal homeostasis, regular hair follicle morphogenesis and cycling.[2] Cathepsin L is involved in protein degradation.[3] It might regulate normal functioning of the immune system.[2] Cathepsin L regulates the death of macrophages, necrotic core formation and development of atherosclerotic plaque instability.[4]
Aplicación
Cathepsin L is a lysosomal cysteine proteinase that metabolizes collagens and elastins. The roles and activity of Cathepsin L can be studied with the aid of peptide inhibitors such as the pentapeptide amide RKLLW-NH2 (Arg-Lys-Leu-Leu-Trp-NH2).
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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A Brinker et al.
European journal of biochemistry, 267(16), 5085-5092 (2000-08-10)
By screening a combinatorial pentapeptide amide collection in an inhibition assay, we systematically evaluated the potential of 19 proteinogenic amino acids and seven nonproteinogenic amino acids to serve as building blocks for inhibitors of human cathepsin L. Particularly efficient were
Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis
Li W, et al.
Atherosclerosis, 202(1), 92-102 (2009)
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells
Liu J, et al.
Atherosclerosis, 184(2), 302-311 (2006)
Protease signalling: the cutting edge
Turk B, et al.
The Embo Journal, 31(7), 1630-1643 (2012)
Brendan Reed et al.
The Journal of experimental medicine, 218(2) (2020-10-24)
The identification of the peptide epitopes presented by major histocompatibility complex class II (MHCII) molecules that drive the CD4 T cell component of autoimmune diseases has presented a formidable challenge over several decades. In type 1 diabetes (T1D), recent insight
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Do you have any references for product SCP0110, Cathepsin L Inhibitor?
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Product SCP0110, Cathepsin L inhibitor peptide has the sequence Arg-Lys-Leu-Leu-Trp-NH2, which can be abbreviated RKLLW-NH2.See the following paper for reference: A. Brinker, et al.: Eur. J. Biochem., 267(16), 5085-5092 (2000). Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections.
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