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Merck
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SCP0038

Sigma-Aldrich

Amyloid β 1-42 rat

≥90% (HPLC)

Sinónimos:

β-Amyloid 1-42, Amyloid for Rat, Rat Amyloid β 1-42

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500 μG
US$ 499,00
1 MG
US$ 745,00

US$ 499,00

PRECIOS SIN IMPUESTOS NACIONALES
Normalmente se envía en 2 semanas.
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500 μG
US$ 499,00
1 MG
US$ 745,00

About This Item

Fórmula empírica (notación de Hill):
C199H307N53O59S1
Peso molecular:
4417.95
Código UNSPSC:
12352200
NACRES:
NA.32

US$ 499,00

PRECIOS SIN IMPUESTOS NACIONALES
Normalmente se envía en 2 semanas.
Solicitar un pedido a granel

Ensayo

≥90% (HPLC)

Formulario

lyophilized

composición

Peptide Content, ≥75%

condiciones de almacenamiento

protect from light

temp. de almacenamiento

−20°C

Categorías relacionadas

Amino Acid Sequence

Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

Descripción general

Amyloid β (Aβ) 1-42 is the major Aβ species in the amyloid plaques that develop in the case of Alzheimer′s disease (AD). It has a cross-β structure with parallel, in-register β-sheets.

Aplicación

Amyloid β 1-42 rat has been used as an amyloid β (Aβ) oligomer in intracerebroventricular (ICV) injection/intra-hippocampal infusion to establish the Alzheimer′s disease (AD) model in rat.

Acciones bioquímicas o fisiológicas

Amyloid β 1-42 forms amyloid fibrils more readily compared to Aβ(1–40), in vitro. Aβ1-42 injections are known to cause brain dysfunction indicating learning and memory deficits. Amyloid β (Aβ) refers to peptides derived from amyloid precursor protein that vary in length from 37–43 amino acids. Aβ(s) peptides, their peptide fragments, and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding, and mechanisms of protein cross-linking in the context of diseases such as Alzheimer′s disease and neurodegeneration.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
E1375
E1327
E1271
E1246
E1221

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Enes Akyuz et al.
Biomedicines, 8(3) (2020-03-19)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a complex etiology and characterized by cognitive deficits and memory loss. The pathogenesis of AD is not yet completely elucidated, and no curative treatment is currently available. Inwardly rectifying potassium (Kir)
Jing Wang et al.
Molecular medicine reports, 23(6) (2021-04-22)
Ginkgolide B (GB), the diterpenoid lactone compound isolated from the extracts of Ginkgo biloba leaves, significantly improves cognitive impairment, but its potential pharmacological effect on astrocytes induced by β‑amyloid (Aβ)1‑42 remains to be elucidated. The present study aimed to investigate the
Rat Hair Metabolomics Analysis Reveals Perturbations of Unsaturated Fatty Acid Biosynthesis, Phenylalanine, and Arachidonic Acid Metabolism Pathways Are Associated with Amyloid-I?-Induced Cognitive Deficits.
Tan, et al.
Molecular Neurobiology (2023)
Zhifeng Tian et al.
Journal of integrative neuroscience, 18(3), 309-312 (2019-10-12)
Alzheimer's disease is pathologically characterized by the presence of senile plaques and neurofibrillary tangles in the central nervous system. Amyloid β-protein is toxic to neurons and induces phosphorylation of Tau protein, which accumulates in paired helical filaments and leads to
Raheleh Farahzadi et al.
ACS chemical neuroscience, 11(10), 1424-1435 (2020-04-21)
Mesenchymal stem cells (MSCs) are of particular interest because of their potential in regenerative medicine. Stem cell-based therapies cast a new hope for neurodegenerative disease treatment as a regeneration strategy, including treatment for Alzheimer's disease (AD). A multitude of cytokines
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Questions

  1. What's the preparation instruction and how long is the incubation period?

    1 answer

    1. This product has not been tested for solubility or in vitro use. However there are publications available that may be helpful. Please see the information and links to the articles below:

      Aβ1-42 was dissolved in sterile water at a concentration of 2 mmol/L and incubated at 37 °C for 24 h.
      https://www.nature.com/articles/aps2013203

      A solution of 200 ng/μL concentration of Aβ was prepared in PBS (0.1 M). The solution of Aβ was incubated for 5 days at 37⁰C, and before injection, PBS was added to the solution to reach a final concentration of 10 ng/μL.
      https://www.researchgate.net/publication/346096849_Original_Article_Improvement_of_Learning_and_Memory_Deficits_With_Aerobic_Training_and_Donepezil_Co-therapy_in_Amyloid-b_beta-injected_Male_Rats_Through_the_CREB_and_BDNF_Signaling_Pathway

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