SAB5700455

Anti-Phospho-PLCG2-Y759 antibody produced in rabbit

• Sinónimos: APLAID, FCAS3, PLC-IV, PLC-gamma-2, PLCG2
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 147
• species reactivity: human
• concentration: 1.87 mg/ml
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: P16885
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr759)
• Gene Information: human ... PLCG2(5336)

Descripción

General description

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.

Immunogen

A synthetic phosphorylated peptide around Y759 of human PLCG2 (NP_002652.2).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable