Inhibitor of growth-family member 1 (ING1) possesses plant homeodomains (PHDs). The gene ID of the protein is 26356.
Specificity
Detects a ~33 kDa protein corresponding to the molecular mass of p33 ING1 on SDS PAGE immunoblots.
Immunogen
Mouse p33 ING1 N-terminal peptide –KLH conjugates
Biochem/physiol Actions
Inhibitor of growth-family member 1 (ING1) may take part in chromatin remodeling. It is a part of histone acetyltransferase complex and acts as an epigenetic modulator. Like the other members of its family, ING1 also functions as a tumor suppressor.
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Physical form
TBS, 50% glycerol, 0.09% sodium azide
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The INhibitor of Growth (ING) proteins act as type II tumor suppressors and epigenetic regulators, being stoichiometric members of histone acetyltransferase and histone deacetylase complexes. Expression of the alternatively spliced ING1a tumor suppressor increases >10-fold during replicative senescence. ING1a overexpression
The candidate tumor suppressor p33(ING1) plays an important role in inducinggrowth arrest at G(0)-G(1) phase of the cell cycle and/or promoting apoptosis in cancerous cells. p33(ING1) is reported to act as a transcriptional cofactor by associating with tumor suppressor p53
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