SAB4504665

Anti-phospho-BL-CAM (pTyr⁸⁰⁷) antibody produced in rabbit

affinity isolated antibody

• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 95 kDa
• species reactivity: mouse, rat, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:40000; western blot: 1:500-1:1000
• NCBI accession no.: P20273
• UniProt accession no.: P20273
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr807)
• Gene Information: human ... CD22(933)

Descripción

General description

CD22 (cluster of differentiation 22) is a 140 kDa single-spanning membrane glycoprotein present on the surface of B cells. This gene belongs to the sialic acid-binding Ig-type lectin (Siglec) family. CD22 is mapped to human chromosome 19q13.

Immunogen

The antiserum was produced against synthesized peptide derived from human BL-CAM around the phosphorylation site of Tyr807.

Immunogen Range: 776-825

Biochem/physiol Actions

CD22 (cluster of differentiation 22) helps to maintain B-cell homeostasis. This molecule act as an inhibitory coreceptor of the BCR (B cell receptor). CD22 is considered as a response regulator to control several aspects of B cell functions. Deficiency in CD22 or its pathways may contribute to autoimmunity.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable