SAB4503839

Anti-phospho-SYK (pTyr⁵²⁵) antibody produced in rabbit

affinity isolated antibody

• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 72 kDa
• species reactivity: mouse, rat, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P43405
• UniProt accession no.: P43405
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr525)
• Gene Information: human ... SYK(6850)

Descripción

General description

Spleen tyrosine kinase (SYK) is a member of the non-receptor tyrosine kinase family. It is usually expressed in epithelial breast tissues and hematopoietic cells. SYK is mapped to human chromosome 9q22.

Immunogen

The antiserum was produced against synthesized peptide derived from human SYK around the phosphorylation site of Tyr525.

Immunogen Range: 491-540

Application

Anti-phospho-SYK (pTyr525) antibody has been used in immunohistochemistry.

Biochem/physiol Actions

Spleen tyrosine kinase (SYK), as a tumor suppressor gene helps to prevent the development and metastasis of breast cancer cells. It participates in B-cell receptor signaling. This protein helps to phosphorylate the α-tubulin subunits of microtubules.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable