SAB4301248

Anti-phospho-Pim-1 (pTyr³⁰⁹) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: EC 2.7.11.1, PIM-1, Proto-oncogene serine/threonine-protein kinase pim-1
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 45 kDa
• species reactivity: mouse, rat, human
• concentration: 1.0 mg/mL
• technique(s): western blot: 1:500-1:1000 (Cell Lysate)
• isotype: IgG
• accession no.: NP_001230115.1
• UniProt accession no.: P11309
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr309)
• Gene Information: human ... PIM1(5292)

Descripción

General description

Pim-1 proto-oncogene, serine/threonine kinase (PIM1) is expressed at high levels in bone marrow, thymus, spleen, fetal liver, hippocampus, oral epithelium, and the prostate gland. PIM1 gene has five introns and six exons and is mapped to human chromosome 6p21.2.

Specificity

The antibody detects endogenous levels of Pim-1 only when phosphorylated at tyrosine 309.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 309(H-R-Y(p)-H-G) derived from Human Pim-1.

Biochem/physiol Actions

Pim-1 proto-oncogene, serine/threonine kinase (PIM1) modulates cell cycle progression, cellular division, differentiation, and apoptosis. It participates in genomic instability. PIM1 serves as an oncogenic survival factor. PIM1 gene is overexpressed in gastric carcinoma, squamous cell carcinoma, colorectal carcinoma, liver carcinoma, liposarcoma, and bladder cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable