gp120 Antibody: Human immunodeficiency virus type 1 (HIV-1) entry into target cells is directed by the envelope (Env) glycoproteins, which are present on the surface of HIV-1 virion or infected cells in the form of trimers consisting of gp120/gp41 complexes. The surface subunit, gp120, initiates the entry process by interacting sequentially with the CD4 receptor and a co-receptor CCR5 or CXCR4, thereby inducing a conformational change that allows the transmembrane (TM) gp41 subunit to mediate fusion between viral and target cell membranes. Cleavage of Env into its gp120 and gp41 components is necessary for activation of its fusogenic activity.
Inmunógeno
gp120 antibody was raised against 15 amino acids from near the center of gp120.The immunogen is located within amino acids 470 - 520 of gp120.
Aplicación
Gp120 antibody can be used for detection of gp120 by Western blot at 1 μg/mL.
Forma física
Supplied in PBS containing 0.02% sodium azide.
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