TRMT12 (tRNA methyltransferase 12 homolog) gene is localized to human chromosome 8q24, and is a homolog of yeast gene coding for a tRNA methyltransferase.
Immunogen
Antibody was raised against a 19 amino acid peptide near the amino terminus of human TYW2.
Biochem/physiol Actions
TRMT12 (tRNA methyltransferase 12 homolog) gene is amplified and over-expressed in breast cancer. This enzyme is responsible for catalyzing the third step in wybutosine biosynthetic pathway. In cancer, up-regulation of this gene leads to disruption in SMG1 protein function, which is a part of nonsense mediated decay pathway (NMD). Thus, it might contribute to the escape of damaged DNA from checkpoints.
Features and Benefits
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Linkage
The action of this antibody can be blocked using blocking peptide SBP3500666.
Physical form
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
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Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer.
Rodriguez V et al
Genes Chromosomes Cancer, 46(7), 694-707 (2007)
TRMT12 overexpression in cancer cells affects the cell cycle and the nonsense mediated decay pathways by regulating the SMG-1 kinase, a member of the PIKK family of kinases.
Rodriguez V et al
Cancer Research, 69(9), 2486-2486 (2009)
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