Fem-1 homolog A (FEM1A) is a homolog of the Fem-1 gene of Caenorhabditis elegans. It is predicted to encode an ankyrin repeat proteins which is expressed in many tissues. FEM1A is a conserved VHL-box protein. The gene encoding it is localized on human chromosome 19p13.3.
Inmunógeno
Peptide with sequence CGFIPEDLEAFIELH, from the C Terminus of the protein sequence according to NP_061178.1.
Acciones bioquímicas o fisiológicas
Fem-1 homolog A (FEM1A) is a substrate recognition subunit of cullin-2-RING E3 ubiquitin ligase complex. It has a role in the degradation of stem-loop binding protein (SLBP) and may be involved in anti-inflammatory signaling. FEM1A has been associated with polycystic ovary syndrome.
Características y beneficios
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Forma física
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
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FEM1 proteins are ancient regulators of SLBP degradation.
Dankert JF
Cell Cycle (2017)
FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome.
Goodarzi MO
Human Reproduction (2008)
The Fem1c genes: conserved members of the Fem1 gene family in vertebrates.
Ventura-Holman
Gene (2003)
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