Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. (provided by RefSeq)
Inmunógeno
ADRA1A (NP_150646, 1 a.a. ~ 27 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence MVFLSGNASDSSNCTQPPAPVNISKAI
Forma física
Solution in phosphate buffered saline, pH 7.4
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Molecular biology of the cell, 22(8), 1227-1239 (2011-02-25)
In the vertebrate neuroepithelium, the decision to differentiate is made by neural precursors soon after mitosis, when they are apically located. This process is controlled by lateral inhibitory signals triggered by the Delta/Notch pathway. During mitosis, the capacity of neural
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