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Merck

S6047

Sigma-Aldrich

Saccharin sodium salt hydrate

BioXtra, ≥99%

Sinónimos:

2,3-Dihydro-3-oxobenzisosulfonazole sodium salt, 2-Sulfobenzoic acid imide sodium salt, o-Sulfobenzimide sodium salt, Saccharin soluble

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About This Item

Fórmula empírica (notación de Hill):
C7H4NNaO3S · xH2O
Número de CAS:
Peso molecular:
205.17 (anhydrous basis)
Beilstein/REAXYS Number:
3599229
EC Number:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25

product line

BioXtra

assay

≥99%

form

powder

sweetness

300 × sucrose

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.001%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES string

[Na+].[H]O[H].[O-]C1=NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S.Na.H2O/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;;/h1-4H,(H,8,9);;1H2/q;+1;/p-1

InChI key

ILJOYZVVZZFIKA-UHFFFAOYSA-M

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General description

Saccharin is an artificial sweetener, which is used in canned fruit juices, vegetables, cookies and jellies. It is associated with bladder cancer.

Application

Saccharin sodium salt hydrate has been used to eliminate the potentially confounding effect of caloric content. It has also been used to study its effects on the cyclamate-responsive taste 2 receptor member 1 (TAS2R1) receptor.

Biochem/physiol Actions

′First generation′ synthetic sugar alternative that has been studied for its carcinogenic potential.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Spectrophotometric method for the determination of saccharin in food and pharmaceutical products
Mathew SB, et al.
Indian Journal of Pharmaceutical Sciences, 68(6), 821-821 (2006)
FGF21 regulates sweet and alcohol preference
Talukdar S, et al.
Cell Metabolism, 23(2), 344-349 (2016)
Blends of non-caloric sweeteners saccharin and cyclamate show reduced off-taste due to TAS2R bitter receptor inhibition
Behrens M, et al.
Cell Chemical Biology, 24(10), 1199-1204 (2017)
Simone Rehn et al.
Physiology & behavior, 207, 15-27 (2019-05-06)
When animals are given access to a palatable food or drink on some days but not on others, the amount they consume can far exceed the daily amounts consumed by controls given daily access. A previous study demonstrated such bingeing
Robert A Boakes et al.
Physiology & behavior, 218, 112822-112822 (2020-02-01)
Rats first given 24-h access to 10% sucrose for 4 or 12 days (Stage 1) were then switched to a saccharin solution for a 12-day Stage 2. The initial result of this switch was that these Sucrose groups drank less

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