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S0274

Sigma-Aldrich

[D-Arg1, D-Trp7,9, Leu11]-Substance P acetate salt

≥97% (HPLC)

Sinónimos:

Spantide I

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About This Item

Fórmula empírica (notación de Hill):
C75H108N20O13 · xC2H4O2
Número de CAS:
91224-37-2
Peso molecular:
1497.79 (free base basis)
UNSPSC Code:
12352200

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCCCN)NC(=O)[C@@H]7CCCN7C(=O)[C@H](N)CCCNC(N)=N)C(N)=O

Gene Information

human ... TACR1(6869)
mouse ... TACR1(21336)
rat ... TACR1(24807)

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Leu-Leu-NH2

Biochem/physiol Actions

Potent NK-1 tachykinin receptor antagonist.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
080H58552
067K12861
067K1286
080H5855
080H58556

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Sharon A McClellan et al.
Investigative ophthalmology & visual science, 49(4), 1502-1511 (2008-04-04)
Studies have shown that blocking substance P (SP) binding to neurokinin 1 receptor with spantide I prevents Pseudomonas aeruginosa-induced corneal perforation in susceptible C57BL/6 mice. This study tested the effect of SP injection on the resistance response (cornea heals) of
Zimei Zhou et al.
Investigative ophthalmology & visual science, 49(10), 4458-4467 (2008-06-21)
Apoptosis was examined after Pseudomonas aeruginosa corneal infection in C57BL/6 (B6, susceptible) and BALB/c (resistant) mice. TUNEL staining, real-time RT-PCR, polymorphonuclear neutrophils (PMNs) and macrophage (Mphi) depletion, and immunostaining were used. Intense TUNEL staining was seen in BALB/c versus B6
A C Broiz et al.
Neuroscience, 201, 134-145 (2011-11-30)
The dorsal periaqueductal gray (dPAG) is the main output structure for the defensive response to proximal aversive stimulation. Panic-like responses, such as freezing and escape behaviors, often result when this structure is electrically stimulated. Freezing also ensues after termination of
Jeffrey Tessier et al.
Infection and immunity, 75(4), 1895-1903 (2007-01-31)
Bacillus anthracis edema toxin (ET), composed of protective antigen and an adenylate cyclase edema factor (EF), elicits edema in host tissues, but the target cells and events leading from EF-mediated cyclic-AMP production to edema are unknown. We evaluated the direct
Qing Lin et al.
Molecular pain, 3, 30-30 (2007-10-27)
Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs). Inflammatory neuropeptides are suggested to be released from primary afferent nociceptors participating in
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