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Merck

S009

Sigma-Aldrich

LY-165,163

solid

Sinónimos:

4-[2-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]ethyl]benzeneamine, p-Aminophenethyl-m-trifluoromethylphenyl piperazine, PAPP

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About This Item

Fórmula empírica (notación de Hill):
C19H22F3N3
Número de CAS:
Peso molecular:
349.39
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

form

solid

Quality Level

color

off-white

solubility

0.1 M HCl: slightly soluble
H2O: insoluble
ethanol: freely soluble

SMILES string

Nc1ccc(CCN2CCN(CC2)c3cccc(c3)C(F)(F)F)cc1

InChI

1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2

InChI key

GAAKALASJNGQKD-UHFFFAOYSA-N

Gene Information

Biochem/physiol Actions

Selective 5-HT1A serotonin receptor agonist and 5-HT1D serotonin receptor antagonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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P H Hutson et al.
European journal of pharmacology, 143(2), 221-228 (1987-11-10)
The putative 5-HT1A agonist 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (LY165163, PAPP) (1, 2, 4, 10 mg/kg s.c.) caused a significant and dose-dependent hypothermia in rats, 30 and 60 min after injection. The decreases of temperature were less marked than that caused by 8-OH-DPAT 1
T P Donohoe et al.
Psychopharmacology, 93(1), 82-86 (1987-01-01)
The putative serotonin (5-HT)1A agonist 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluormethylphenyl) piperazine (LY165163, PAPP) induces hyperphagia and hypothermia in rats, but unlike other 5-HT agonists, does not induce 5-HT stereotypy even at high doses (10 mg/kg sc). LY165163 (1 mg/kg) increased striatal DOPA accumulation in
M J Millan et al.
The Journal of pharmacology and experimental therapeutics, 269(1), 121-131 (1994-04-01)
In view of the involvement of central alpha 1-adrenoceptors in the expression of 5-HT1A receptor-mediated spontaneous tail-flicks (STFs) in the rat, this study examined whether the putative alpha 1-adrenoceptor antagonist (alpha 1-antagonist) properties of certain 5-HT1A receptor agonists, (+)-flesinoxan and
M L Cohen et al.
Life sciences, 38(1), 1-5 (1986-01-06)
The nature of the receptor mediating serotonin contraction in the rat stomach fundus has not been clearly associated with either 5HT1 or 5HT2 receptors. We have explored the possibility that such receptors in the rat fundus may better correlate with
Alireza Nasoori
Biological reviews of the Cambridge Philosophical Society, 95(4), 986-1019 (2020-04-28)
This review describes the formation, structure, and function of bony compartments in antlers, horns, ossicones, osteoderm and the os penis/os clitoris (collectively referred to herein as AHOOO structures) in extant mammals. AHOOOs are extra-skeletal bones that originate from subcutaneous (dermal)

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