PZ0407

PF-04957325

≥98% (HPLC)

• Sinónimos: 3-[[(2R)-4-(2-Thiazolylmethyl)-2-morpholinyl]methyl]-5-(trifluoromethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine, 3-[[(2R)-4-(thiazol-2-ylmethyl)morpholin-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine
• Fórmula empírica (notación de Hill): C₁₄H₁₅F₃N₈OS
• Número de CAS: 1305115-80-3
• Peso molecular: 400.38
• MDL number: MFCD22665721
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: FC(F)(C1=NC2=C(C(N)=N1)N=NN2C[C@@H]3OCCN(C3)CC4=NC=CS4)F

Descripción

Biochem/physiol Actions

PF-04957325 is a cAMP-competitive, potent and selective phosphodiesterase 8 inhibitor (IC50 = 3.05 nM/PDE8A, 0.44 nM/PDE8B, 1 μM/PDE4D with 12-14 nM cAMP; >1 μM/all other PDEs).

Información de seguridad

• pictograms: GHS02
• signalword: Danger
• hcodes: H242
• pcodes: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Storage Class: 5.2 - Organic peroxides and self-reacting hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable