P9156
Plasminogen from bovine plasma
lyophilized powder, ≥2.0 units/mg protein
Sinónimos:
Profibrinolysin
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Número de CAS:
EC Number:
MDL number:
UNSPSC Code:
12352202
eCl@ss:
42030240
NACRES:
NA.61
Productos recomendados
biological source
bovine plasma
form
lyophilized powder
specific activity
≥2.0 units/mg protein
concentration
2-7% protein (biuret)
suitability
not suitable for streptokinase determination by clot formation procedure
application(s)
histology
storage temp.
2-8°C
Gene Information
cow ... PLG(280897)
human ... PLG(5340)
Biochem/physiol Actions
The activated form of plasminogen, plasmin, was shown to promote the migration of melanoma and lung tumor cells plated on the extracellular matrix protein laminin by altering protein kinase C signaling.
Plasminogen is the inactive precursor of the protease plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration. Plasmin cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. It is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).
Other Notes
ε-Aminocaproic acid free
Unit Definition
One unit will produce 1.0 μmole of p-nitroanilide from D-Val-Leu-Lys 4-nitroanilide at pH 7.5 at 37°C.
Physical form
Lyophilized powder containing NaCl, EDTA, lysine, and Tris buffer salts
Reconstitution
Solutions should be stored in buffer containing 20 mM lysine at neutral pH. The protein should be as concentrated as possible. Frozen in aliquots at −20 °C, it should be stable for several weeks.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
L Chikahisa et al.
Invasion & metastasis, 17(6), 323-333 (1997-01-01)
Using a pure chemotactic model, we investigated the effect of plasmin on tumor cell motility. In the presence of various extracellular matrix proteins, plasmin facilitated motility of human melanoma LOX and lung cancer Lu-99 cells. Laminin contributed most to the
Sudan Puri et al.
Stem cell research & therapy, 13(1), 384-384 (2022-07-31)
Hyaluronan (HA) has previously been identified as an integral component of the limbal stem cell niche in vivo. In this study, we investigated whether a similar HA matrix is also expressed in vitro providing a niche supporting limbal epithelial stem
Liver-artery interactions via the plasminogen-CD36 axis in macrophage foam cell formation: new evidence for the role of remote organ crosstalk in atherosclerosis.
Hiroshi Iwata et al.
Circulation, 127(11), 1173-1176 (2013-03-20)
Wei-Bin Cai et al.
PloS one, 7(12), e53152-e53152 (2013-01-10)
We had demonstrated that plasminogen kringle 5 (K5), a potent angiogenic inhibitor, inhibited retinal neovascularization and hepatocellular carcinoma growth by anti-angiogenesis. The current study investigated the effects and the underlying mechanisms of K5 on both tumor growth and spontaneous pulmonary
Katie M Weigandt et al.
Biophysical journal, 103(11), 2399-2407 (2013-01-04)
Using a combination of structural and mechanical characterization, we examine the effect of fibrinogen oxidation on the formation of fibrin clots. We find that treatment with hypochlorous acid preferentially oxidizes specific methionine residues on the α, β, and γ chains
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico