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P0248

Sigma-Aldrich

PNU-37883A

≥98% (HPLC), powder

Sinónimos:

N-(1-Adamantyl)-N′-cyclohexyl-4-morpholinecarboxamidine hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C21H36ClN3O
Número de CAS:
57568-80-6
Peso molecular:
381.98
MDL number:
MFCD06798347
UNSPSC Code:
12352200
PubChem Substance ID:
24277692

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: ~23 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

Cl.C1CCC(CC1)\N=C(/NC23CC4CC(CC(C4)C2)C3)N5CCOCC5

Gene Information

human ... KCNJ8(3764)

Biochem/physiol Actions

Selective inhibitor of Kir6.1/SUR2B channels.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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H Kovalev et al.
British journal of pharmacology, 141(5), 867-873 (2004-02-06)
1. In this study, we have used Kir6.1/Kir6.2 chimeric proteins and current recordings to investigate the molecular basis of PNU-37883A inhibition of cloned K(ATP) channels. 2. Rat Kir6.1, Kir6.2 and Kir6.1/Kir6.2 chimeras were co-expressed with either SUR2B or SUR1, following
Bobby D Nossaman et al.
Journal of cardiovascular pharmacology, 50(4), 358-366 (2007-12-01)
The free radical peroxynitrite (ONOO-) is formed in biological systems from the reaction of nitric oxide (NO) with superoxide (O2-) and can react with protein and nonprotein thiol groups to produce tissue injury. However, these pathologic actions of (ONOO-) may
Mariko Yamanaka et al.
International immunopharmacology, 2(13-14), 1957-1964 (2002-12-20)
It is suggested that attenuation of the renal kallikrein-kinin system (KKS) involved the development of hypertension in young spontaneously hypertensive rats (SHR). In the present study, a comparison was made between young SHR and Wistar Kyoto rats (WKY) to examine
Cheng-Yuan Hsu et al.
Shock (Augusta, Ga.), 37(6), 653-658 (2012-05-04)
In clinical practice, prolonged occlusion of main arteries causes accumulation of metabolic waste and lactate. Reperfusion of blood flow is usually accompanied by circulatory shock. This study investigates the molecular mechanisms responsible for acidosis-induced hypotension and proposes therapeutic strategies for
Yoshihiro Suzuki et al.
International journal of oncology, 41(2), 465-475 (2012-05-23)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is promising for cancer treatment owing to its selective cytotoxicity against malignant cells. However, some cancer cell types, including malignant melanoma cells, are resistant to TRAIL-induced apoptosis. Therefore, drugs that can amplify TRAIL cytotoxicity
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