Product O9389, Oltipraz, has no Retest or Expiration Date. There are a number of products with the only date shown on the lot-specific Certificate of Analysis being the Release Date. For these products there is no stated Retest, Expiration or Use-by-Date Date. We recommend handling per defined conditions as printed in our product literature and website product descriptions. Products should be routinely inspected by the customer to ensure they perform as expected.
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O9389
Oltipraz
≥98% (HPLC), powder
Sinónimos:
4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione, BRN 0978110, CCRIS 4048, NSC 347901, RP 35972
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5 MG
US$ 135,00
25 MG
US$ 544,00
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5 MG
US$ 135,00
25 MG
US$ 544,00
About This Item
Fórmula empírica (notación de Hill):
C8H6N2S3
Número de CAS:
Peso molecular:
226.34
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
red
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
CC1=C(SSC1=S)c2cnccn2
InChI
1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3
InChI key
CKNAQFVBEHDJQV-UHFFFAOYSA-N
General description
Biochem/physiol Actions
Oltipraz is an activator of Nrf2.
Oltipraz is an activator of Nrf2. Nrf2 (NF-E2-related factor 2) is a transcription factor that binds to antioxidant response elements (AREs) and activates these genes. Oltipraz activates Nrf2 and subsequently elevates expression of the detoxification genes encoding anti-oxidant and multidrug resistance-associated proteins to mediate its chemopreventive efficacy.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Los clientes también vieron
Min Kyung Kang et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 12(1), 1-16 (2009-05-28)
To evaluate the pharmacokinetic interaction between oltipraz and silymarin after intravenous and oral administration of both drugs to male Sprague-Dawley rats. Oltipraz (single doses of 10 and 30 mg/kg for intravenous and oral administration, respectively), silymarin (single doses of 50
Yoko Yagishita et al.
Antioxidants (Basel, Switzerland), 9(8) (2020-08-14)
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the regulation of inflammation and cellular detoxication pathways. The contribution of the NRF2
Samuel Carroll Brooks et al.
Pharmacology & therapeutics, 124(1), 31-43 (2009-07-01)
Comprehensive studies support the notion that oltipraz [4-methyl-5-(2-pyrazynyl)-1,2-dithiole-3-thione] and its congeners exert cancer chemopreventive effects by the prevention, inhibition or reversal of carcinogenic processes. Recently, it was found that dithiolethione compounds had the activities to prevent or treat fibrosis, insulin
Ryan Holland et al.
Chemical research in toxicology, 22(8), 1427-1434 (2009-09-30)
The ability of three dithiolethione cancer chemopreventives, oltipraz 1, anetholedithione (ADT) 2, 1,2-dithiole-3-thione (D3T) 3, and the major metabolite, 4, of 1, to induce the cytoprotective enzyme NQO1 in Hepa 1c1c7 cells and the inhibition of this induction by catalase
Song Hwa Choi et al.
Expert opinion on drug metabolism & toxicology, 6(2), 213-224 (2010-01-26)
Comprehensive studies indicate that oltipraz exerts cancer chemopreventive effects. Oltipraz has other therapeutic potentials, which include anti-fibrotic effect, inhibition of insulin resistance, mitochondrial protection and cytoprotective effect against oxidative stress. Although antioxidant mechanisms may account for its cancer chemopreventive effect
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