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Documentos

N4411

Sigma-Aldrich

NU6027

≥98% (HPLC)

Sinónimos:

4-Cyclohexylmethoxy-2,6-diamino-5-nitrosopyrimidine

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About This Item

Fórmula empírica (notación de Hill):
C11H17N5O2
Número de CAS:
220036-08-8
Peso molecular:
251.28
MDL number:
MFCD05664735
UNSPSC Code:
12352200
PubChem Substance ID:
24724550
NACRES:
NA.77

assay

≥98% (HPLC)

form

solid

color

lavender

mp

252.5-253.7 °C (lit.)

solubility

DMSO: 15 mg/mL

storage temp.

2-8°C

SMILES string

O=NC1=C(N)N=C(N)N=C1OCC2CCCCC2

InChI

1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)

InChI key

DGWXOLHKVGDQLN-UHFFFAOYSA-N

Gene Information

human ... CDK2(1017) , MGMT(4255)

Biochem/physiol Actions

NU6027 is a potent inhibitor of ATR signalling
Selective cyclin-dependent kinase-2 (CDK2) inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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A Peasland et al.
British journal of cancer, 105(3), 372-381 (2011-07-07)
The ataxia telangiectasia mutated and Rad3-related kinase (ATR) has a key role in the signalling of stalled replication forks and DNA damage to cell cycle checkpoints and DNA repair. It has long been recognised as an important target for cancer
Rebeka Sultana et al.
PloS one, 8(2), e57098-e57098 (2013-03-02)
Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repair. XRCC1 is a critical enzyme in single strand break repair and base
Jie Chen et al.
DNA repair, 73, 55-63 (2018-11-25)
The ataxia telangiectasia-mutated and Rad3-related (ATR) serine/threonine kinase plays a central role in the repair of replication-associated DNA damage, the maintenance of S and G2/M-phase genomic stability, and the promotion of faithful mitotic chromosomal segregation. A number of stimuli activate
Sarah Akbib et al.
PloS one, 14(2), e0212210-e0212210 (2019-02-20)
Cell therapy for diabetes could benefit from the identification of small-molecule compounds that increase the number of functional pancreatic beta cells. Using a newly developed screening assay, we previously identified glucocorticoids as potent stimulators of human and rat beta cell
Benjamin A Hilton et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(9), 3882-3893 (2017-05-19)
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder that is caused by a point mutation in the LMNA gene, resulting in production of a truncated farnesylated-prelamin A protein (progerin). We previously reported that XPA mislocalized to the progerin-induced DNA
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