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L2400

Lavendustin A

Name: Lavendustin A
Brand: SIGMA

~85% (TLC), crystalline

Sinónimos:

5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid

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About This Item

Fórmula empírica (notación de Hill):

C₂₁H₁₉NO₆

Número de CAS:

125697-92-9

Peso molecular:

381.38

Número MDL:

MFCD00153822

Código UNSPSC:

12352200

ID de la sustancia en PubChem:

24896314

Ensayo

~85% (TLC)

Formulario

crystalline

solubilidad

DMSO: soluble
methanol: soluble

temp. de almacenamiento

−20°C

cadena SMILES

OC(=O)c1cc(ccc1O)N(Cc2ccccc2O)Cc3cc(O)ccc3O

InChI

1S/C21H19NO6/c23-16-6-8-19(25)14(9-16)12-22(11-13-3-1-2-4-18(13)24)15-5-7-20(26)17(10-15)21(27)28/h1-10,23-26H,11-12H2,(H,27,28)

Clave InChI

ULTTYPMRMMDONC-UHFFFAOYSA-N

Información sobre el gen

human ... EGFR(1956) , ERBB2(2064) , LCK(3932)

Acciones bioquímicas o fisiológicas

Cell-permeable tyrosine kinase inhibitor with little effect on protein kinase A or C. Inhibits NMDA-stimulated cGMP production. Inhibits VEGF-induced angiogenesis.

Forma física

Photosensitive

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

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Modulation of AMPA excitatory postsynaptic currents in the spinal cord dorsal horn neurons by insulin.

D Spicarova et al.

Neuroscience, 166(1), 305-311 (2009-12-17)

Glutamate AMPA receptors are critical for sensory transmission at the spinal cord dorsal horn (DH). Plasma membrane AMPA receptor endocytosis that can be induced by insulin may underlie long term modulation of synaptic transmission. Insulin receptors (IRs) are known to

Effects of monocarboxylic acid-derived Cl- channel blockers on depolarization-activated potassium currents in rat ventricular myocytes.

Shi-Sheng Zhou et al.

Experimental physiology, 92(3), 549-559 (2007-02-17)

The effects of monocarboxylic acid-derived Cl(-) channel blockers on cardiac depolarization-activated K(+) currents were investigated. Membrane currents in rat ventricular myocytes were recorded using the whole-cell configuration of the patch-clamp technique. 5-Nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) and niflumic acid (NFA) induced an

Protein tyrosine kinase is required for the induction of long-term potentiation in the rat hippocampus.

C C Huang et al.

The Journal of physiology, 520 Pt 3, 783-796 (1999-11-02)

1. Protein tyrosine phosphorylation is thought to play an important role in the regulation of neuronal function. Previous work has shown that protein tyrosine kinase (PTK) inhibitors can inhibit the induction of long-term potentiation (LTP), a candidate synaptic mechanism involved

Influence of the tyrosine kinase inhibitors STI571 (Glivec), lavendustin A and genistein on human mast cell line (HMC-1(560)) activation.

Kristin Löber et al.

Journal of cellular biochemistry, 103(4), 1076-1088 (2007-07-31)

The human mast cell line (HMC-1(560)) was used to study the effects of tyrosine kinase (TyrK) inhibition on histamine release in consequence of intracellular Ca2+ or pH changes. This is important since the TyrK inhibitor STI571 (Glivec) inhibits proliferation and

Inhibition of atrial wall stretch-induced cardiac hormone secretion by lavendustin A, a potent tyrosine kinase inhibitor.

P Taskinen et al.

Endocrinology, 140(9), 4198-4207 (1999-08-28)

The cellular processes linking mechanical wall stretch to atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) secretion from the heart are unclear. In the present study, a paced perfused rat heart preparation was used to study the signaling mechanisms

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