I5029
IgG1, Lambda from human myeloma plasma
purified immunoglobulin, >95% (SDS-PAGE)
Sinónimos:
Human IgG1-λ
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origen biológico
human
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
purified immunoglobulin
Ensayo
>95% (SDS-PAGE)
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
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Descripción general
IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections.[1] IgG1 is the most abundant of the IgG subclass
Human myeloma IgG1, λ is purified from human plasma by fractionation, ion-exchange, and affinity chromatography procedures.
Human myeloma IgG1, λ is purified from human plasma by fractionation, ion-exchange, and affinity chromatography procedures.
IgG is the main antibody type found in plasma and extracellular fluid and is expressed on B cell membrane. IgG is further subdivided into four subclass- IgG1, IgG2, IgG3 and IgG4.Elevation in antigen specific IgG1 is associated with symptomatic infection and Th2-regulation[2]. IgG1 λ from human myeloma can be used in quantitative ELISA[3].Human IgG1 λ react specifically with human IgG.
Aplicación
IgG1 λ from human myeloma can be used as reference antigen, blocking agent, immunoglobulin calibrator or coating protein in various immunoassay like ELISA, dot blot immunobinding, immunodiffusion, immunoelectrophoresis, hemagglutination, cell-binding assays and western immunoblotting[4].
The purified IgG1, λ may be used as an immunoglobulin calibrator, reference antigen, blocking agent or coating protein in a variety of immunoassays including ELISA, dot-blot immunobinding, Western immunoblotting, immunodiffusion, immunoelectrophoresis, hemagglutination, and cell-binding assays. Human myeloma IgG1, λ was used as non-specific control in quantitative ELISA and solid-phase ELISA.[5] A range of concentrations of IgG1, λ from 10 to 100 ng was used for quantitative ELISA.[6] Human myeloma IgG1, λ was also used as control in size-exclusion chromatography to analyse purity of recombinant antibodies.[7]
Forma física
Solution in 0.02 M Tris buffered saline, pH 8.0.
Nota de análisis
Identity is determined by immunoelectrophoresis and indirect ELISA.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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W L Zhao et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 36(2), 271-278 (2021-10-28)
The detection of serum anti-desmoglein (Dsg) IgG autoantibodies has been reported to be useful for assessment of disease activity in pemphigus. However, previous studies have reported that anti-Dsg autoantibodies remain detectable in some patients without active pemphigus lesions. To investigate
Ken Ishii et al.
The Journal of investigative dermatology, 140(10), 1919-1926 (2020-03-07)
Anti-desmoglein (Dsg) 1 and Dsg3 IgG autoantibodies in pemphigus foliaceus and pemphigus vulgaris cause blisters through loss of desmosomal adhesion. It is controversial whether blister formation is due to direct inhibition of Dsg, intracellular signaling events causing desmosome destabilization, or
A M Lew
Journal of immunological methods, 72(1), 171-176 (1984-08-03)
The antibody titre and the optical density values in an ELISA are influenced by the epitope density of the antigen and the affinity of the antibody tested. This has major implications in the interpretation of ELISA results.
M J Day
Veterinary parasitology, 147(1-2), 2-8 (2007-05-01)
Infection with Leishmania may have different outcomes in genetically distinct individuals and the course of infection is determined by the nature of the host innate and adaptive immune response. Thus in experimentally infected mice, and in naturally infected dogs or
Julie Jacobs et al.
Oncotarget, 8(43), 74058-74067 (2017-11-02)
In contrast to the negligible expression of the immunomodulating protein CD70 in normal tissue, we have demonstrated constitutive overexpression of CD70 on tumor cells in a subset of primary non-small cell lung cancer (NSCLC) biopsies. This can be exploited by
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