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I1774

Sigma-Aldrich

Iturin A from Bacillus subtilis

≥95% (HPLC), suitable for microbiological culture

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About This Item

Número de CAS:
52229-90-0
MDL number:
MFCD01094135
UNSPSC Code:
12352202
NACRES:
NA.61

product name

Iturin A from Bacillus subtilis, ≥95% (HPLC)

biological source

Bacillus subtilis

Quality Level

200

assay

≥95% (HPLC)

form

powder

technique(s)

microbiological culture: suitable

color

white to yellow

solubility

ethanol: soluble 9.80-10.20 mg/mL

antibiotic activity spectrum

fungi

mode of action

cell membrane | interferes

storage temp.

2-8°C

Application

Iturin A was used in the study of Bacillomycin D (an iturin with antifungal activity against Aspergillus flavus).

Biochem/physiol Actions

IturinA exhibits strong antifungal activity against pathogenic yeast and fungi. It interacts with the cytoplasmic membrane of the target cell forming ion conducting pores. Its mode of action could be attributed to its interaction with sterols and phospholipids. The compound causes the release of exo-vesicles from human erythrocytes.

Other Notes

A family of lipopeptides characterized by a heptapeptide cyclized with a C13-C17 β-amino fatty acid. Composed mainly of C14-C15 β-amino acids.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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S Mizumoto et al.
Applied microbiology and biotechnology, 75(6), 1267-1274 (2007-04-25)
Enhanced production of the antibiotic iturin A by Bacillus subtilis RB14-CS reached 4.4 g L(-1) in SM medium containing soybean meal and maltose, which was 16-fold and 2.2-fold higher than that in original and modified number 3S media, respectively. When
Jun Yuan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(26), 2746-2750 (2011-08-30)
Iturin A, a powerful antifungal surfactant, is a kind of bacterial lipopeptide produced by Bacillus strains. This study addresses the use of an aqueous two-phase system (ATPS) using ethanol/ammonium sulfate to extract iturin A from Bacillus amyloliquefaciens NJN-6 fermentation broth
Chie Niisawa et al.
The Journal of general and applied microbiology, 54(3), 149-158 (2008-07-26)
A composting product of marine animal resources has been used as a fertilizer and a soil conditioner in Japan. This compost was produced by a repeated fed-batch fermentation system with three successive aerobic bioreactors. Composting temperature reached about 75 degrees
Minakshi Grover et al.
Current microbiology, 60(2), 99-106 (2009-09-25)
Bacillus subtilis strain RP24, isolated from rhizoplane of field grown pigeon pea, exhibited in vitro antagonism against a wide range of phytopathogenic fungi. An attempt was made to partially purify and characterize the diffusible antifungal metabolite/s produced by the strain
Katarzyna Czaczyk et al.
Polish journal of microbiology, 57(4), 313-319 (2008-01-01)
Cell surface hydrophobicity (CSH) is recognised as a important factor in microbial adhesion to solid surfaces. Growth conditions have been found to determine the synthesis of extracellular molecules by microorganisms. It has major consequences in modification of bacterial surface properties
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